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VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion.
Brain Res. 2001 Jan 26; 890(1):184-8.BR

Abstract

Immunohistochemistry for VR1, a nociceptive transducer for vanilloid compounds, protons and heat (>43 degrees C), was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 20% of TG cells and these neurons were mostly small- to medium-sized (mean+/-S.D. 427+/-189 microm(2)). Twenty-six percent of the TG neurons retrogradely labeled from the facial skin exhibited VR1-IR, while the IR was detected in only 8% of those labeled from the tooth pulp. Co-expression of VR1 was common among the calcitonin gene-related peptide-immunoreactive cutaneous neurons (63%) but not among the similar tooth pulp neurons (20%). The present study indicates that primary nociceptive neurons which respond to vanilloid compounds, protons and heat are abundant in the facial skin but not in the tooth pulp.

Authors+Show Affiliations

Second Department of Oral Anatomy and Biodental Research Center, Okayama University Dental School, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. hiroichi@dent.okayama-u.ac.jpNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11164782

Citation

Ichikawa, H, and T Sugimoto. "VR1-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Ganglion." Brain Research, vol. 890, no. 1, 2001, pp. 184-8.
Ichikawa H, Sugimoto T. VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Res. 2001;890(1):184-8.
Ichikawa, H., & Sugimoto, T. (2001). VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Research, 890(1), 184-8.
Ichikawa H, Sugimoto T. VR1-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Ganglion. Brain Res. 2001 Jan 26;890(1):184-8. PubMed PMID: 11164782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion. AU - Ichikawa,H, AU - Sugimoto,T, PY - 2001/2/13/pubmed PY - 2001/5/1/medline PY - 2001/2/13/entrez SP - 184 EP - 8 JF - Brain research JO - Brain Res. VL - 890 IS - 1 N2 - Immunohistochemistry for VR1, a nociceptive transducer for vanilloid compounds, protons and heat (>43 degrees C), was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 20% of TG cells and these neurons were mostly small- to medium-sized (mean+/-S.D. 427+/-189 microm(2)). Twenty-six percent of the TG neurons retrogradely labeled from the facial skin exhibited VR1-IR, while the IR was detected in only 8% of those labeled from the tooth pulp. Co-expression of VR1 was common among the calcitonin gene-related peptide-immunoreactive cutaneous neurons (63%) but not among the similar tooth pulp neurons (20%). The present study indicates that primary nociceptive neurons which respond to vanilloid compounds, protons and heat are abundant in the facial skin but not in the tooth pulp. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/11164782/VR1_immunoreactive_primary_sensory_neurons_in_the_rat_trigeminal_ganglion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(00)03253-4 DB - PRIME DP - Unbound Medicine ER -