Tags

Type your tag names separated by a space and hit enter

Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetes mellitus subjects with good glycaemic control.
Diabetes Res Clin Pract. 2001 Feb; 51(2):107-14.DR

Abstract

OBJECTIVES

To compare cardiovascular risk factors and LDL particle size in well-controlled Type 2 diabetes mellitus and normal subjects.

METHODS

Ninety-three Type 2 diabetic males and 186 age-matched, male controls were studied. Glycaemic control was stable for at least 3 months prior to recruitment. None were on insulin or lipid lowering therapy. Anthropometric indices, blood pressure, lipids, glucose, insulin, apolipoprotein A1 and B, LDL subfraction by density ultracentrifugation were obtained after an overnight fast of 10 h.

RESULTS

Diabetic subjects (mean HbA(1c) 6.6%+/-0.10) did not differ from controls in total cholesterol levels (5.04+/-0.08 vs. 5.16+/-0.05 mmol/l, respectively) but had lower serum HDL cholesterol (0.98+/-0.03 vs. 1.12+/-0.02 mmol/l, P<0.001), higher serum triglyceride (2.38+/-0.16 vs. 1.80+/-0.08 mmol/l, P<0.001), lower LDL(1) and LDL(2) and higher LDL(3) concentration. An LDL(3) concentration exceeding 100 mg/dl was found in 59.1% of diabetics and 39.1% of non-diabetics (P<0.001). Diabetic subjects also had higher body mass index, waist to hip ratio and insulin resistance (HOMA). Difference in LDL subfraction between groups disappeared after adjustments were made for either triglyceride or HDL cholesterol.

CONCLUSION

Well controlled Type 2 diabetes mellitus subjects exhibit an increased cardiovascular burden through low HDL cholesterol and predominance of small, dense LDL particles.

Authors+Show Affiliations

Department of Endocrinology, Singapore General Hospital, Outram Road, 169608, Singapore City, Singapore. ce_tan@sgh.gov.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11165690

Citation

Tan, C E., et al. "Cardiovascular Risk Factors and LDL Subfraction Profile in Type 2 Diabetes Mellitus Subjects With Good Glycaemic Control." Diabetes Research and Clinical Practice, vol. 51, no. 2, 2001, pp. 107-14.
Tan CE, Chew LS, Chio LF, et al. Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetes mellitus subjects with good glycaemic control. Diabetes Res Clin Pract. 2001;51(2):107-14.
Tan, C. E., Chew, L. S., Chio, L. F., Tai, E. S., Lim, H. S., Lim, S. C., Jayakumar, L., Eng, H. K., & Packard, C. J. (2001). Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetes mellitus subjects with good glycaemic control. Diabetes Research and Clinical Practice, 51(2), 107-14.
Tan CE, et al. Cardiovascular Risk Factors and LDL Subfraction Profile in Type 2 Diabetes Mellitus Subjects With Good Glycaemic Control. Diabetes Res Clin Pract. 2001;51(2):107-14. PubMed PMID: 11165690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetes mellitus subjects with good glycaemic control. AU - Tan,C E, AU - Chew,L S, AU - Chio,L F, AU - Tai,E S, AU - Lim,H S, AU - Lim,S C, AU - Jayakumar,L, AU - Eng,H K, AU - Packard,C J, PY - 2001/2/13/pubmed PY - 2001/4/21/medline PY - 2001/2/13/entrez SP - 107 EP - 14 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 51 IS - 2 N2 - OBJECTIVES: To compare cardiovascular risk factors and LDL particle size in well-controlled Type 2 diabetes mellitus and normal subjects. METHODS: Ninety-three Type 2 diabetic males and 186 age-matched, male controls were studied. Glycaemic control was stable for at least 3 months prior to recruitment. None were on insulin or lipid lowering therapy. Anthropometric indices, blood pressure, lipids, glucose, insulin, apolipoprotein A1 and B, LDL subfraction by density ultracentrifugation were obtained after an overnight fast of 10 h. RESULTS: Diabetic subjects (mean HbA(1c) 6.6%+/-0.10) did not differ from controls in total cholesterol levels (5.04+/-0.08 vs. 5.16+/-0.05 mmol/l, respectively) but had lower serum HDL cholesterol (0.98+/-0.03 vs. 1.12+/-0.02 mmol/l, P<0.001), higher serum triglyceride (2.38+/-0.16 vs. 1.80+/-0.08 mmol/l, P<0.001), lower LDL(1) and LDL(2) and higher LDL(3) concentration. An LDL(3) concentration exceeding 100 mg/dl was found in 59.1% of diabetics and 39.1% of non-diabetics (P<0.001). Diabetic subjects also had higher body mass index, waist to hip ratio and insulin resistance (HOMA). Difference in LDL subfraction between groups disappeared after adjustments were made for either triglyceride or HDL cholesterol. CONCLUSION: Well controlled Type 2 diabetes mellitus subjects exhibit an increased cardiovascular burden through low HDL cholesterol and predominance of small, dense LDL particles. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/11165690/Cardiovascular_risk_factors_and_LDL_subfraction_profile_in_Type_2_diabetes_mellitus_subjects_with_good_glycaemic_control_ DB - PRIME DP - Unbound Medicine ER -