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Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats.
J Biochem Mol Toxicol. 2001; 15(1):41-6.JB

Abstract

Coenzyme Q10 is an endogenous lipid soluble antioxidant. Because oxidant stress may exacerbate some complications of diabetes mellitus, this study investigated the effects of subacute treatment with exogenous coenzyme Q10 (10 mg/kg/day, i.p. for 14 days) on tissue antioxidant defenses in 30-day streptozotocin-induced diabetic Sprague-Dawley rats. Liver, kidney, brain, and heart were assayed for degree of lipid peroxidation, reduced and oxidized glutathione contents, and activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase. All tissues from diabetic animals exhibited increased oxidative stress and disturbances in antioxidant defense when compared with normal controls. Treatment with the lipophilic compound coenzyme Q10 reversed diabetic effects on hepatic glutathione peroxidase activity, on renal superoxide dismutase activity, on cardiac lipid peroxidation, and on oxidized glutathione concentration in brain. However, treatment with coenzyme Q10 also exacerbated the increase in cardiac catalase activity, which was already elevated by diabetes, further decreased hepatic glutathione reductase activity, augmented the increase in hepatic lipid peroxidation, and further increased glutathione peroxidase activity in the heart and brain of diabetic animals. Subacute dosing with coenzyme Q10 ameliorated some of the diabetes-induced changes in oxidative stress. However, exacerbation of several diabetes-related effects was also observed.

Authors+Show Affiliations

Medical Sciences Program, Indiana University School of Medicine, Bloomington 47405-7005, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11170314

Citation

Rauscher, F M., et al. "Effects of Coenzyme Q10 Treatment On Antioxidant Pathways in Normal and Streptozotocin-induced Diabetic Rats." Journal of Biochemical and Molecular Toxicology, vol. 15, no. 1, 2001, pp. 41-6.
Rauscher FM, Sanders RA, Watkins JB. Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 2001;15(1):41-6.
Rauscher, F. M., Sanders, R. A., & Watkins, J. B. (2001). Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats. Journal of Biochemical and Molecular Toxicology, 15(1), 41-6.
Rauscher FM, Sanders RA, Watkins JB. Effects of Coenzyme Q10 Treatment On Antioxidant Pathways in Normal and Streptozotocin-induced Diabetic Rats. J Biochem Mol Toxicol. 2001;15(1):41-6. PubMed PMID: 11170314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats. AU - Rauscher,F M, AU - Sanders,R A, AU - Watkins,J B,3rd PY - 2001/2/15/pubmed PY - 2001/5/18/medline PY - 2001/2/15/entrez SP - 41 EP - 6 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 15 IS - 1 N2 - Coenzyme Q10 is an endogenous lipid soluble antioxidant. Because oxidant stress may exacerbate some complications of diabetes mellitus, this study investigated the effects of subacute treatment with exogenous coenzyme Q10 (10 mg/kg/day, i.p. for 14 days) on tissue antioxidant defenses in 30-day streptozotocin-induced diabetic Sprague-Dawley rats. Liver, kidney, brain, and heart were assayed for degree of lipid peroxidation, reduced and oxidized glutathione contents, and activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase. All tissues from diabetic animals exhibited increased oxidative stress and disturbances in antioxidant defense when compared with normal controls. Treatment with the lipophilic compound coenzyme Q10 reversed diabetic effects on hepatic glutathione peroxidase activity, on renal superoxide dismutase activity, on cardiac lipid peroxidation, and on oxidized glutathione concentration in brain. However, treatment with coenzyme Q10 also exacerbated the increase in cardiac catalase activity, which was already elevated by diabetes, further decreased hepatic glutathione reductase activity, augmented the increase in hepatic lipid peroxidation, and further increased glutathione peroxidase activity in the heart and brain of diabetic animals. Subacute dosing with coenzyme Q10 ameliorated some of the diabetes-induced changes in oxidative stress. However, exacerbation of several diabetes-related effects was also observed. SN - 1095-6670 UR - https://www.unboundmedicine.com/medline/citation/11170314/Effects_of_coenzyme_Q10_treatment_on_antioxidant_pathways_in_normal_and_streptozotocin_induced_diabetic_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1095-6670&date=2001&volume=15&issue=1&spage=41 DB - PRIME DP - Unbound Medicine ER -