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Neuroprotective constituents from Hedyotis diffusa.
J Nat Prod. 2001 Jan; 64(1):75-8.JN

Abstract

In a bioassay-guided search for neuroprotective compounds from medicinal plants, a MeOH extract of whole plants of Hedoytis diffusa yielded five flavonol glycosides, kaempferol 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-galactopyranoside (1), quercetin 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-galactopyranoside (2), quercetin 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-glucopyranoside (3), kaempferol 3-O-(2-O-beta-D-glucopyranosyl)-beta-D-galactopyranoside (4), and quercetin 3-O-(2-O-beta-D-glucopyranosyl)-beta-D-galactopyranoside (5), and four O-acylated iridoid glycosides (6-9). Compounds 1 and 2 are previously unreported natural products, and all nine compounds exhibited significant neuroprotective activity in primary cultures of rat cortical cells damaged by L-glutamate.

Authors+Show Affiliations

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11170670

Citation

Kim, Y, et al. "Neuroprotective Constituents From Hedyotis Diffusa." Journal of Natural Products, vol. 64, no. 1, 2001, pp. 75-8.
Kim Y, Park EJ, Kim J, et al. Neuroprotective constituents from Hedyotis diffusa. J Nat Prod. 2001;64(1):75-8.
Kim, Y., Park, E. J., Kim, J., Kim, Y., Kim, S. R., & Kim, Y. Y. (2001). Neuroprotective constituents from Hedyotis diffusa. Journal of Natural Products, 64(1), 75-8.
Kim Y, et al. Neuroprotective Constituents From Hedyotis Diffusa. J Nat Prod. 2001;64(1):75-8. PubMed PMID: 11170670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective constituents from Hedyotis diffusa. AU - Kim,Y, AU - Park,E J, AU - Kim,J, AU - Kim,Y, AU - Kim,S R, AU - Kim,Y Y, PY - 2001/2/15/pubmed PY - 2001/6/22/medline PY - 2001/2/15/entrez SP - 75 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 64 IS - 1 N2 - In a bioassay-guided search for neuroprotective compounds from medicinal plants, a MeOH extract of whole plants of Hedoytis diffusa yielded five flavonol glycosides, kaempferol 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-galactopyranoside (1), quercetin 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-galactopyranoside (2), quercetin 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-glucopyranoside (3), kaempferol 3-O-(2-O-beta-D-glucopyranosyl)-beta-D-galactopyranoside (4), and quercetin 3-O-(2-O-beta-D-glucopyranosyl)-beta-D-galactopyranoside (5), and four O-acylated iridoid glycosides (6-9). Compounds 1 and 2 are previously unreported natural products, and all nine compounds exhibited significant neuroprotective activity in primary cultures of rat cortical cells damaged by L-glutamate. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/11170670/Neuroprotective_constituents_from_Hedyotis_diffusa_ L2 - https://doi.org/10.1021/np000327d DB - PRIME DP - Unbound Medicine ER -