Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors.Biochem Soc Trans. 2000 Dec; 28(6):785-9.BS
Abstract
The essential steps of the novel non-mevalonate pathway of isopentenyl diphosphate and isoprenoid biosynthesis in plants are described. The first five enzymes and genes of this 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway are known. The herbicide fosmidomycin specifically blocks the second enzyme, the DOXP reductoisomerase. The DOXP/MEP pathway is also present in several pathogenic bacteria and the malaria parasite. Hence, all herbicides and inhibitors blocking this novel isoprenoid pathway in plants are also potential drugs against malaria and diseases caused by pathogenic bacteria.
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Review
Language
eng
PubMed ID
11171208
Citation
Lichtenthaler, H K.. "Non-mevalonate Isoprenoid Biosynthesis: Enzymes, Genes and Inhibitors." Biochemical Society Transactions, vol. 28, no. 6, 2000, pp. 785-9.
Lichtenthaler HK. Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors. Biochem Soc Trans. 2000;28(6):785-9.
Lichtenthaler, H. K. (2000). Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors. Biochemical Society Transactions, 28(6), 785-9.
Lichtenthaler HK. Non-mevalonate Isoprenoid Biosynthesis: Enzymes, Genes and Inhibitors. Biochem Soc Trans. 2000;28(6):785-9. PubMed PMID: 11171208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors.
A1 - Lichtenthaler,H K,
PY - 2001/2/15/pubmed
PY - 2001/6/2/medline
PY - 2001/2/15/entrez
SP - 785
EP - 9
JF - Biochemical Society transactions
JO - Biochem Soc Trans
VL - 28
IS - 6
N2 - The essential steps of the novel non-mevalonate pathway of isopentenyl diphosphate and isoprenoid biosynthesis in plants are described. The first five enzymes and genes of this 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway are known. The herbicide fosmidomycin specifically blocks the second enzyme, the DOXP reductoisomerase. The DOXP/MEP pathway is also present in several pathogenic bacteria and the malaria parasite. Hence, all herbicides and inhibitors blocking this novel isoprenoid pathway in plants are also potential drugs against malaria and diseases caused by pathogenic bacteria.
SN - 0300-5127
UR - https://www.unboundmedicine.com/medline/citation/11171208/Non_mevalonate_isoprenoid_biosynthesis:_enzymes_genes_and_inhibitors_
DB - PRIME
DP - Unbound Medicine
ER -
