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Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women.

Abstract

BACKGROUND

-Dietary animal fat and protein have been inversely associated with a risk of intraparenchymal hemorrhage in ecological studies.

METHODS AND RESULTS

In 1980, 85 764 women in the Nurses' Health Study cohort, who were 34 to 59 years old and free of diagnosed cardiovascular disease and cancer, completed dietary questionnaires. From these questionnaires, we calculated fat and protein intake. By 1994, after 1.16 million person-years of follow-up, 690 incident strokes, including 74 intraparenchymal hemorrhages, had been documented. Multivariate-adjusted risk of intraparenchymal hemorrhage was higher among women in the lowest quintile of energy-adjusted saturated fat intake than at all higher levels of intake (relative risk [RR], 2.36; 95% CI, 1.10 to 5.09; P:=0.03). For trans unsaturated fat, the corresponding RR was 2.50 (95% CI, 1.35 to 4.65; P:=0.004). Animal protein intake was inversely associated with risk (RR in the highest versus lowest quintiles, 0.32; 95% CI, 0.10 to 1.00; P:=0.04). The excess risk associated with low saturated fat intake was observed primarily among women with a history of hypertension (RR, 3.66; 95% CI, 1.09 to 12.3; P=0.04), but such an interaction was not seen for trans unsaturated fat or animal protein. These nutrients were not related to risk of other stroke subtypes. Dietary cholesterol and monounsaturated and polyunsaturated fat were not related to risk of any stroke subtype.

CONCLUSIONS

Low intake of saturated fat and animal protein was associated with an increased risk of intraparenchymal hemorrhage, which may help to explain the high rate of this stroke subtype in Asian countries. The increased risk with low intake of saturated fat and trans unsaturated fat is compatible with the reported association between low serum total cholesterol and risk.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

    , , , , , , ,

    Source

    Circulation 103:6 2001 Feb 13 pg 856-63

    MeSH

    Adult
    Cerebral Hemorrhage
    Cholesterol
    Cholesterol, Dietary
    Cohort Studies
    Dietary Fats
    Dietary Proteins
    Exercise
    Fatty Acids, Omega-3
    Female
    Humans
    Hypertension
    Incidence
    Life Style
    Medical Records
    Multivariate Analysis
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11171795

    Citation

    Iso, H, et al. "Prospective Study of Fat and Protein Intake and Risk of Intraparenchymal Hemorrhage in Women." Circulation, vol. 103, no. 6, 2001, pp. 856-63.
    Iso H, Stampfer MJ, Manson JE, et al. Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women. Circulation. 2001;103(6):856-63.
    Iso, H., Stampfer, M. J., Manson, J. E., Rexrode, K., Hu, F., Hennekens, C. H., ... Willett, W. C. (2001). Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women. Circulation, 103(6), pp. 856-63.
    Iso H, et al. Prospective Study of Fat and Protein Intake and Risk of Intraparenchymal Hemorrhage in Women. Circulation. 2001 Feb 13;103(6):856-63. PubMed PMID: 11171795.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women. AU - Iso,H, AU - Stampfer,M J, AU - Manson,J E, AU - Rexrode,K, AU - Hu,F, AU - Hennekens,C H, AU - Colditz,G A, AU - Speizer,F E, AU - Willett,W C, PY - 2001/2/15/pubmed PY - 2001/4/21/medline PY - 2001/2/15/entrez SP - 856 EP - 63 JF - Circulation JO - Circulation VL - 103 IS - 6 N2 - BACKGROUND: -Dietary animal fat and protein have been inversely associated with a risk of intraparenchymal hemorrhage in ecological studies. METHODS AND RESULTS: In 1980, 85 764 women in the Nurses' Health Study cohort, who were 34 to 59 years old and free of diagnosed cardiovascular disease and cancer, completed dietary questionnaires. From these questionnaires, we calculated fat and protein intake. By 1994, after 1.16 million person-years of follow-up, 690 incident strokes, including 74 intraparenchymal hemorrhages, had been documented. Multivariate-adjusted risk of intraparenchymal hemorrhage was higher among women in the lowest quintile of energy-adjusted saturated fat intake than at all higher levels of intake (relative risk [RR], 2.36; 95% CI, 1.10 to 5.09; P:=0.03). For trans unsaturated fat, the corresponding RR was 2.50 (95% CI, 1.35 to 4.65; P:=0.004). Animal protein intake was inversely associated with risk (RR in the highest versus lowest quintiles, 0.32; 95% CI, 0.10 to 1.00; P:=0.04). The excess risk associated with low saturated fat intake was observed primarily among women with a history of hypertension (RR, 3.66; 95% CI, 1.09 to 12.3; P=0.04), but such an interaction was not seen for trans unsaturated fat or animal protein. These nutrients were not related to risk of other stroke subtypes. Dietary cholesterol and monounsaturated and polyunsaturated fat were not related to risk of any stroke subtype. CONCLUSIONS: Low intake of saturated fat and animal protein was associated with an increased risk of intraparenchymal hemorrhage, which may help to explain the high rate of this stroke subtype in Asian countries. The increased risk with low intake of saturated fat and trans unsaturated fat is compatible with the reported association between low serum total cholesterol and risk. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/11171795/Prospective_study_of_fat_and_protein_intake_and_risk_of_intraparenchymal_hemorrhage_in_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11171795.ui DB - PRIME DP - Unbound Medicine ER -