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Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies.

Abstract

During investigation of a food-borne outbreak of hepatitis A among university students in a southwestern metropolitan community, immune electron microscopic examination of a concentrated stool suspension pooled from seven acutely ill individuals revealed viruslike particles 17-nm in diameter. These particles were initially coated by antibody contained in the convalescent-phase serum of one of the ill students as well ad by antibody in convalescent plasma of a prison volunteer originally infected with the MS-1 strain of hepatitis A virus. Rises in titer of antibody to this particle were demonstrated by immune electron microscopy in acute and convalescent sera from student patients as well as in pre-inoculation and convalescent sera from the prison volunteer. Two chimpanzees inoculated intravenously with the concentrated preparation of pooled human stools developed viral hepatitis. During acute illness their feces contained particles morphologically identical to those in the inoculum. These findings represent the first reported recovery of the presumed etiologic agent of hepatitis A from a naturally occurring community outbreak of disease in the United States.

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  • Publisher Full Text
  • Authors

    , , , , ,

    Source

    The Journal of infectious diseases 131:2 1975 Feb pg 167-71

    MeSH

    Acute Disease
    Animals
    Antibodies, Viral
    Antigen-Antibody Reactions
    Antigens, Viral
    Arizona
    Disease Outbreaks
    Feces
    Food Contamination
    Hepatitis A
    Humans
    Inclusion Bodies, Viral
    Microscopy, Electron
    Pan troglodytes

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    1117190

    Citation

    Gravelle, C R., et al. "Hepatitis A: Report of a Common-source Outbreak With Recovery of a Possible Etiologic Agent. II. Laboratory Studies." The Journal of Infectious Diseases, vol. 131, no. 2, 1975, pp. 167-71.
    Gravelle CR, Hornbeck CL, Maynard JE, et al. Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies. J Infect Dis. 1975;131(2):167-71.
    Gravelle, C. R., Hornbeck, C. L., Maynard, J. E., Schable, C. A., Cook, E. H., & Bradley, D. W. (1975). Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies. The Journal of Infectious Diseases, 131(2), pp. 167-71.
    Gravelle CR, et al. Hepatitis A: Report of a Common-source Outbreak With Recovery of a Possible Etiologic Agent. II. Laboratory Studies. J Infect Dis. 1975;131(2):167-71. PubMed PMID: 1117190.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies. AU - Gravelle,C R, AU - Hornbeck,C L, AU - Maynard,J E, AU - Schable,C A, AU - Cook,E H, AU - Bradley,D W, PY - 1975/2/1/pubmed PY - 1975/2/1/medline PY - 1975/2/1/entrez SP - 167 EP - 71 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 131 IS - 2 N2 - During investigation of a food-borne outbreak of hepatitis A among university students in a southwestern metropolitan community, immune electron microscopic examination of a concentrated stool suspension pooled from seven acutely ill individuals revealed viruslike particles 17-nm in diameter. These particles were initially coated by antibody contained in the convalescent-phase serum of one of the ill students as well ad by antibody in convalescent plasma of a prison volunteer originally infected with the MS-1 strain of hepatitis A virus. Rises in titer of antibody to this particle were demonstrated by immune electron microscopy in acute and convalescent sera from student patients as well as in pre-inoculation and convalescent sera from the prison volunteer. Two chimpanzees inoculated intravenously with the concentrated preparation of pooled human stools developed viral hepatitis. During acute illness their feces contained particles morphologically identical to those in the inoculum. These findings represent the first reported recovery of the presumed etiologic agent of hepatitis A from a naturally occurring community outbreak of disease in the United States. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/1117190/Hepatitis_A:_report_of_a_common_source_outbreak_with_recovery_of_a_possible_etiologic_agent__II__Laboratory_studies_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/131.2.167 DB - PRIME DP - Unbound Medicine ER -