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Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies.
J Infect Dis 1975; 131(2):167-71JI

Abstract

During investigation of a food-borne outbreak of hepatitis A among university students in a southwestern metropolitan community, immune electron microscopic examination of a concentrated stool suspension pooled from seven acutely ill individuals revealed viruslike particles 17-nm in diameter. These particles were initially coated by antibody contained in the convalescent-phase serum of one of the ill students as well ad by antibody in convalescent plasma of a prison volunteer originally infected with the MS-1 strain of hepatitis A virus. Rises in titer of antibody to this particle were demonstrated by immune electron microscopy in acute and convalescent sera from student patients as well as in pre-inoculation and convalescent sera from the prison volunteer. Two chimpanzees inoculated intravenously with the concentrated preparation of pooled human stools developed viral hepatitis. During acute illness their feces contained particles morphologically identical to those in the inoculum. These findings represent the first reported recovery of the presumed etiologic agent of hepatitis A from a naturally occurring community outbreak of disease in the United States.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1117190

Citation

Gravelle, C R., et al. "Hepatitis A: Report of a Common-source Outbreak With Recovery of a Possible Etiologic Agent. II. Laboratory Studies." The Journal of Infectious Diseases, vol. 131, no. 2, 1975, pp. 167-71.
Gravelle CR, Hornbeck CL, Maynard JE, et al. Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies. J Infect Dis. 1975;131(2):167-71.
Gravelle, C. R., Hornbeck, C. L., Maynard, J. E., Schable, C. A., Cook, E. H., & Bradley, D. W. (1975). Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies. The Journal of Infectious Diseases, 131(2), pp. 167-71.
Gravelle CR, et al. Hepatitis A: Report of a Common-source Outbreak With Recovery of a Possible Etiologic Agent. II. Laboratory Studies. J Infect Dis. 1975;131(2):167-71. PubMed PMID: 1117190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies. AU - Gravelle,C R, AU - Hornbeck,C L, AU - Maynard,J E, AU - Schable,C A, AU - Cook,E H, AU - Bradley,D W, PY - 1975/2/1/pubmed PY - 1975/2/1/medline PY - 1975/2/1/entrez SP - 167 EP - 71 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 131 IS - 2 N2 - During investigation of a food-borne outbreak of hepatitis A among university students in a southwestern metropolitan community, immune electron microscopic examination of a concentrated stool suspension pooled from seven acutely ill individuals revealed viruslike particles 17-nm in diameter. These particles were initially coated by antibody contained in the convalescent-phase serum of one of the ill students as well ad by antibody in convalescent plasma of a prison volunteer originally infected with the MS-1 strain of hepatitis A virus. Rises in titer of antibody to this particle were demonstrated by immune electron microscopy in acute and convalescent sera from student patients as well as in pre-inoculation and convalescent sera from the prison volunteer. Two chimpanzees inoculated intravenously with the concentrated preparation of pooled human stools developed viral hepatitis. During acute illness their feces contained particles morphologically identical to those in the inoculum. These findings represent the first reported recovery of the presumed etiologic agent of hepatitis A from a naturally occurring community outbreak of disease in the United States. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/1117190/Hepatitis_A:_report_of_a_common_source_outbreak_with_recovery_of_a_possible_etiologic_agent__II__Laboratory_studies_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/131.2.167 DB - PRIME DP - Unbound Medicine ER -