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No correlation between wine intolerance and histamine content of wine.

Abstract

BACKGROUND

Histamine is thought to be the main cause of adverse reactions to wines.

OBJECTIVE

The purpose of this study was to test the hypothesis that the level of histamine in wine affects the tolerance to wine in 16 subjects with wine intolerance.

METHODS

We performed a study to examine the effects of wine histamine content in 16 adults with wine intolerance. Each subject underwent 2 double-blind provocation tests with wine: 1 with a wine poor in histamine (0.4 mg/L), and 1 with a wine rich in histamine (13.8 mg/L). Blood was collected for histamine and methylhistamine RIAs at 0, 10, 30, and 45 minutes after ingestion of the wine. Methylhistamine and methylimidazolacetic acid (gas chromatography and mass spectrometry) were measured in urine 5 hours before and 5 hours after ingestion.

RESULTS

No significant differences in the occurrence of adverse reactions were noted after ingestion of either of the wines (McNemar test). At 10 minutes, a significant increase was observed in plasma histamine with histamine-poor wine. No significant changes (Wilcoxon test) were observed in the methylhistamine and methylimidazolacetic acid levels after ingestion of either histamine-poor or histamine-rich wine.

CONCLUSION

This study demonstrates that there is no correlation between the histamine content of wine and wine intolerance. The increase of plasma histamine levels at 10 minutes with histamine-poor wine suggested the role of a histamine-releasing substance. The role of acetaldehyde is discussed.

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  • Authors+Show Affiliations

    ,

    Médecine Interne, Immunologie Clinique et Allergologie, Hôpital Central, Nancy, France.

    , , , , , ,

    Source

    MeSH

    Adult
    Female
    Food Hypersensitivity
    Histamine
    Humans
    Male
    Methylhistamines
    Middle Aged
    Urticaria
    Wine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11174207

    Citation

    Kanny, G, et al. "No Correlation Between Wine Intolerance and Histamine Content of Wine." The Journal of Allergy and Clinical Immunology, vol. 107, no. 2, 2001, pp. 375-8.
    Kanny G, Gerbaux V, Olszewski A, et al. No correlation between wine intolerance and histamine content of wine. J Allergy Clin Immunol. 2001;107(2):375-8.
    Kanny, G., Gerbaux, V., Olszewski, A., Frémont, S., Empereur, F., Nabet, F., ... Moneret-Vautrin, D. A. (2001). No correlation between wine intolerance and histamine content of wine. The Journal of Allergy and Clinical Immunology, 107(2), pp. 375-8.
    Kanny G, et al. No Correlation Between Wine Intolerance and Histamine Content of Wine. J Allergy Clin Immunol. 2001;107(2):375-8. PubMed PMID: 11174207.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - No correlation between wine intolerance and histamine content of wine. AU - Kanny,G, AU - Gerbaux,V, AU - Olszewski,A, AU - Frémont,S, AU - Empereur,F, AU - Nabet,F, AU - Cabanis,J C, AU - Moneret-Vautrin,D A, PY - 2001/2/15/pubmed PY - 2001/4/6/medline PY - 2001/2/15/entrez SP - 375 EP - 8 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 107 IS - 2 N2 - BACKGROUND: Histamine is thought to be the main cause of adverse reactions to wines. OBJECTIVE: The purpose of this study was to test the hypothesis that the level of histamine in wine affects the tolerance to wine in 16 subjects with wine intolerance. METHODS: We performed a study to examine the effects of wine histamine content in 16 adults with wine intolerance. Each subject underwent 2 double-blind provocation tests with wine: 1 with a wine poor in histamine (0.4 mg/L), and 1 with a wine rich in histamine (13.8 mg/L). Blood was collected for histamine and methylhistamine RIAs at 0, 10, 30, and 45 minutes after ingestion of the wine. Methylhistamine and methylimidazolacetic acid (gas chromatography and mass spectrometry) were measured in urine 5 hours before and 5 hours after ingestion. RESULTS: No significant differences in the occurrence of adverse reactions were noted after ingestion of either of the wines (McNemar test). At 10 minutes, a significant increase was observed in plasma histamine with histamine-poor wine. No significant changes (Wilcoxon test) were observed in the methylhistamine and methylimidazolacetic acid levels after ingestion of either histamine-poor or histamine-rich wine. CONCLUSION: This study demonstrates that there is no correlation between the histamine content of wine and wine intolerance. The increase of plasma histamine levels at 10 minutes with histamine-poor wine suggested the role of a histamine-releasing substance. The role of acetaldehyde is discussed. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/11174207/No_correlation_between_wine_intolerance_and_histamine_content_of_wine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(01)01097-1 DB - PRIME DP - Unbound Medicine ER -