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The PUVA-turban as a new option of applying a dilute psoralen solution selectively to the scalp of patients with alopecia areata.
J Am Acad Dermatol. 2001 Feb; 44(2):248-52.JA

Abstract

BACKGROUND

Alopecia areata is a burden for many patients and often resistant, even to extensive therapy. Orally administered PUVA therapy has been shown among numerous systemic and topical treatment modalities to be a therapeutic alternative. However, the clinical use of oral PUVA is often limited by systemic side effects. Bath-PUVA therapy offers an alternative solution because of the negligible systemic absorption of psoralen with this technique. Through use of a "PUVA-turban" it is now possible to administer a dilute bathwater solution containing 8-methoxypsoralen (8-MOP) to the scalp.

OBJECTIVE

The purpose of this study was to determine whether PUVA turban therapy is effective in treating alopecia areata in different clinical stages.

METHODS

We treated 9 patients with severe, rapidly progressing, treatment-resistant alopecia areata with PUVA-turban treatment as a modification of bath-PUVA therapy. At each treatment session a cotton towel was soaked with a 0.0001% 8-MOP solution (1 mg/L) at 37 degrees C, wrung gently to remove excess water, and wrapped around the patient's head in a turban fashion for 20 minutes. This was directly followed by UVA radiation. Treatment sessions were initially performed 3 to 4 times per week.

RESULTS

The cumulative UVA doses given over treatment periods of up to 24 weeks were 60.9 to 178.2 J/cm(2), with single doses ranging from 0.3 to 8.0 J/cm(2). After up to 10 weeks of treatment, hair regrowth could be noticed in 6 of 9 patients. Two patients did not respond to the treatment, and one patient showed only vellus hair regrowth.

CONCLUSION

PUVA-turban therapy can be considered a useful method of administering a dilute psoralen solution selectively to the scalp of patients. It has been shown to be a well-tolerated and, in some patients, efficient therapeutic alternative in the treatment of alopecia areata.

Authors+Show Affiliations

Department of Dermatology, University of Ulm, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11174382

Citation

Behrens-Williams, S C., et al. "The PUVA-turban as a New Option of Applying a Dilute Psoralen Solution Selectively to the Scalp of Patients With Alopecia Areata." Journal of the American Academy of Dermatology, vol. 44, no. 2, 2001, pp. 248-52.
Behrens-Williams SC, Leiter U, Schiener R, et al. The PUVA-turban as a new option of applying a dilute psoralen solution selectively to the scalp of patients with alopecia areata. J Am Acad Dermatol. 2001;44(2):248-52.
Behrens-Williams, S. C., Leiter, U., Schiener, R., Weidmann, M., Peter, R. U., & Kerscher, M. (2001). The PUVA-turban as a new option of applying a dilute psoralen solution selectively to the scalp of patients with alopecia areata. Journal of the American Academy of Dermatology, 44(2), 248-52.
Behrens-Williams SC, et al. The PUVA-turban as a New Option of Applying a Dilute Psoralen Solution Selectively to the Scalp of Patients With Alopecia Areata. J Am Acad Dermatol. 2001;44(2):248-52. PubMed PMID: 11174382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The PUVA-turban as a new option of applying a dilute psoralen solution selectively to the scalp of patients with alopecia areata. AU - Behrens-Williams,S C, AU - Leiter,U, AU - Schiener,R, AU - Weidmann,M, AU - Peter,R U, AU - Kerscher,M, PY - 2001/2/15/pubmed PY - 2001/3/17/medline PY - 2001/2/15/entrez SP - 248 EP - 52 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 44 IS - 2 N2 - BACKGROUND: Alopecia areata is a burden for many patients and often resistant, even to extensive therapy. Orally administered PUVA therapy has been shown among numerous systemic and topical treatment modalities to be a therapeutic alternative. However, the clinical use of oral PUVA is often limited by systemic side effects. Bath-PUVA therapy offers an alternative solution because of the negligible systemic absorption of psoralen with this technique. Through use of a "PUVA-turban" it is now possible to administer a dilute bathwater solution containing 8-methoxypsoralen (8-MOP) to the scalp. OBJECTIVE: The purpose of this study was to determine whether PUVA turban therapy is effective in treating alopecia areata in different clinical stages. METHODS: We treated 9 patients with severe, rapidly progressing, treatment-resistant alopecia areata with PUVA-turban treatment as a modification of bath-PUVA therapy. At each treatment session a cotton towel was soaked with a 0.0001% 8-MOP solution (1 mg/L) at 37 degrees C, wrung gently to remove excess water, and wrapped around the patient's head in a turban fashion for 20 minutes. This was directly followed by UVA radiation. Treatment sessions were initially performed 3 to 4 times per week. RESULTS: The cumulative UVA doses given over treatment periods of up to 24 weeks were 60.9 to 178.2 J/cm(2), with single doses ranging from 0.3 to 8.0 J/cm(2). After up to 10 weeks of treatment, hair regrowth could be noticed in 6 of 9 patients. Two patients did not respond to the treatment, and one patient showed only vellus hair regrowth. CONCLUSION: PUVA-turban therapy can be considered a useful method of administering a dilute psoralen solution selectively to the scalp of patients. It has been shown to be a well-tolerated and, in some patients, efficient therapeutic alternative in the treatment of alopecia areata. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/11174382/The_PUVA_turban_as_a_new_option_of_applying_a_dilute_psoralen_solution_selectively_to_the_scalp_of_patients_with_alopecia_areata_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(01)57950-5 DB - PRIME DP - Unbound Medicine ER -