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ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men.
J Lab Clin Med. 2001 Feb; 137(2):133-40.JL

Abstract

A number of previous investigations showed significant associations between polymorphisms of the vitamin D receptor (VDR) gene and bone mineral density (BMD). BMD is influenced by hormones and the rate of skeletal remodeling. A study was performed to investigate the possible relationship between Apa I, Bsm I, Taq I, and Fok I polymorphisms of the VDR gene and serum 1,25-dihydroxyvitamin D (1,25[OH]2D), osteocalcin, and propeptide of type I collagen (PICP)-markers of bone turnover, total body calcium, and BMD of the total body, radius, lumbar spine, trochanter, and femoral neck-in 39 young adult black men of 20 to 40 years of age and 44 age-, height-, and weight-matched white men. The distribution of each of the four alleles of the VDR genotypes was similar in the two racial groups. The Apa I VDR genotype was associated with serum PICP (P =.0494) but not with serum 1,25(OH)2D or serum osteocalcin. A significant association between the Apa I VDR genotype and BMD of the lumbar spine (P =.0291) was also observed. However, the Bsm I, Taq I, and Fok I genotypes were not significantly associated with BMD or serum osteocalcin, PICP, or 1,25(OH)2D. Multivariate stepwise analysis indicated that (1) the Apa I VDR genotype was associated with BMD of the lumbar spine in the two groups together; with total body calcium and BMD of the total body, radius, trochanter, and femoral neck in the black men; and with BMD of the radius in the white men; analysis also indicated that (2) race was significantly associated with total body calcium and BMD of the total body, lumbar spine, and femoral neck. In summary, the Apa I VDR genotype is associated with serum PICP and BMD at a number of sites but does not contribute to or account for racial differences in BMD in young adult men.

Authors+Show Affiliations

Departments of Medicine, Pharmacology, and Pediatrics, Medical University of South Carolina, Charleston, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11174470

Citation

Bell, N H., et al. "ApaI Polymorphisms of the Vitamin D Receptor Predict Bone Density of the Lumbar Spine and Not Racial Difference in Bone Density in Young Men." The Journal of Laboratory and Clinical Medicine, vol. 137, no. 2, 2001, pp. 133-40.
Bell NH, Morrison NA, Nguyen TV, et al. ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men. J Lab Clin Med. 2001;137(2):133-40.
Bell, N. H., Morrison, N. A., Nguyen, T. V., Eisman, J., & Hollis, B. W. (2001). ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men. The Journal of Laboratory and Clinical Medicine, 137(2), 133-40.
Bell NH, et al. ApaI Polymorphisms of the Vitamin D Receptor Predict Bone Density of the Lumbar Spine and Not Racial Difference in Bone Density in Young Men. J Lab Clin Med. 2001;137(2):133-40. PubMed PMID: 11174470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men. AU - Bell,N H, AU - Morrison,N A, AU - Nguyen,T V, AU - Eisman,J, AU - Hollis,B W, PY - 2001/2/15/pubmed PY - 2001/3/17/medline PY - 2001/2/15/entrez SP - 133 EP - 40 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 137 IS - 2 N2 - A number of previous investigations showed significant associations between polymorphisms of the vitamin D receptor (VDR) gene and bone mineral density (BMD). BMD is influenced by hormones and the rate of skeletal remodeling. A study was performed to investigate the possible relationship between Apa I, Bsm I, Taq I, and Fok I polymorphisms of the VDR gene and serum 1,25-dihydroxyvitamin D (1,25[OH]2D), osteocalcin, and propeptide of type I collagen (PICP)-markers of bone turnover, total body calcium, and BMD of the total body, radius, lumbar spine, trochanter, and femoral neck-in 39 young adult black men of 20 to 40 years of age and 44 age-, height-, and weight-matched white men. The distribution of each of the four alleles of the VDR genotypes was similar in the two racial groups. The Apa I VDR genotype was associated with serum PICP (P =.0494) but not with serum 1,25(OH)2D or serum osteocalcin. A significant association between the Apa I VDR genotype and BMD of the lumbar spine (P =.0291) was also observed. However, the Bsm I, Taq I, and Fok I genotypes were not significantly associated with BMD or serum osteocalcin, PICP, or 1,25(OH)2D. Multivariate stepwise analysis indicated that (1) the Apa I VDR genotype was associated with BMD of the lumbar spine in the two groups together; with total body calcium and BMD of the total body, radius, trochanter, and femoral neck in the black men; and with BMD of the radius in the white men; analysis also indicated that (2) race was significantly associated with total body calcium and BMD of the total body, lumbar spine, and femoral neck. In summary, the Apa I VDR genotype is associated with serum PICP and BMD at a number of sites but does not contribute to or account for racial differences in BMD in young adult men. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/11174470/ApaI_polymorphisms_of_the_vitamin_D_receptor_predict_bone_density_of_the_lumbar_spine_and_not_racial_difference_in_bone_density_in_young_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-2143(01)57446-6 DB - PRIME DP - Unbound Medicine ER -