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Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus.

Abstract

OBJECTIVE

Oral lichen planus (OLP) presents with various clinical forms that can be classified into 2 major types: reticular OLP and atrophic-erosive OLP. Our objective was to investigate immunologic differences between these 2 types.

STUDY DESIGN

We investigated possible immunologic differences between 26 patients with reticular OLP and 26 patients with atrophic-erosive OLP.

RESULTS

No differences were detected in serum Ig levels or complement levels. However, the mean proportions of CD4+CD45RO+ and DR+ lymphocytes were significantly higher in patients with atrophic-erosive OLP than in patients with reticular OLP, whereas the mean proportion of CD8+CD45RA+ lymphocytes was significantly lower in patients with atrophic-erosive OLP.

CONCLUSION

These findings suggest that the 2 clinical types of OLP might have different immunopathogenic mechanisms.

Authors+Show Affiliations

University of Santiago de Compostela and Hospital General de Galicia. t155867002@abonados.cplus.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11174595

Citation

Rodríguez-Núñez, I, et al. "Peripheral T-cell Subsets in Patients With Reticular and Atrophic-erosive Oral Lichen Planus." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 91, no. 2, 2001, pp. 180-8.
Rodríguez-Núñez I, Blanco-Carrión A, García AG, et al. Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(2):180-8.
Rodríguez-Núñez, I., Blanco-Carrión, A., García, A. G., & Rey, J. G. (2001). Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 91(2), 180-8.
Rodríguez-Núñez I, et al. Peripheral T-cell Subsets in Patients With Reticular and Atrophic-erosive Oral Lichen Planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(2):180-8. PubMed PMID: 11174595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus. AU - Rodríguez-Núñez,I, AU - Blanco-Carrión,A, AU - García,A G, AU - Rey,J G, PY - 2001/2/15/pubmed PY - 2001/5/1/medline PY - 2001/2/15/entrez SP - 180 EP - 8 JF - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod VL - 91 IS - 2 N2 - OBJECTIVE: Oral lichen planus (OLP) presents with various clinical forms that can be classified into 2 major types: reticular OLP and atrophic-erosive OLP. Our objective was to investigate immunologic differences between these 2 types. STUDY DESIGN: We investigated possible immunologic differences between 26 patients with reticular OLP and 26 patients with atrophic-erosive OLP. RESULTS: No differences were detected in serum Ig levels or complement levels. However, the mean proportions of CD4+CD45RO+ and DR+ lymphocytes were significantly higher in patients with atrophic-erosive OLP than in patients with reticular OLP, whereas the mean proportion of CD8+CD45RA+ lymphocytes was significantly lower in patients with atrophic-erosive OLP. CONCLUSION: These findings suggest that the 2 clinical types of OLP might have different immunopathogenic mechanisms. SN - 1079-2104 UR - https://www.unboundmedicine.com/medline/citation/11174595/Peripheral_T_cell_subsets_in_patients_with_reticular_and_atrophic_erosive_oral_lichen_planus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1079210401102519 DB - PRIME DP - Unbound Medicine ER -