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(+)-N-Allylnormetazocine (NANM)-like discriminative stimulus effects of N-methyl-D-aspartate (NMDA) antagonists.
Behav Pharmacol. 1990; 1(5):453-458.BP

Abstract

The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohepten-5, 10-imine maleate (MK-801), in male Sprague-Dawley rats trained to discriminate 5 mg/kg (+)-N-allyl-normetazocine (NANM) from saline under a standard two-lever fixed-ratio 32 schedule of food reinforcement. (+) - NANM, PCP and MK-801 dose-dependently substituted for the training dose of (+) - NANM in all rats tested. Conversely, NPC 12626 and CPP produced no more than an average of 73% (+) - NANM-lever responding at doses that also reduced response rates by more than 50% of corresponding control response rates. Methohexital also produced an average of 50% (+) - NANM-lever responding at doses that reduced response rates. In addition to supporting a role for the PCP receptor in transducing the discriminative stimulus effects of (+) - NANM, these results lend further evidence for differences in the behavioral effects of competitive and noncompetitive NMDA antagonists.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 USA Present addresses: J. Willetts, Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA; A. Rice, Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA Correspondence to R.L. Balster, Department of Pharmacology and Toxicology, Box 613 MCV Station, Richmond, VA 23298-0613, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11175430

Citation

Willetts, J., et al. "(+)-N-Allylnormetazocine (NANM)-like Discriminative Stimulus Effects of N-methyl-D-aspartate (NMDA) Antagonists." Behavioural Pharmacology, vol. 1, no. 5, 1990, pp. 453-458.
Willetts J, Rice A, Balster RL. (+)-N-Allylnormetazocine (NANM)-like discriminative stimulus effects of N-methyl-D-aspartate (NMDA) antagonists. Behav Pharmacol. 1990;1(5):453-458.
Willetts, J., Rice, A., & Balster, R. L. (1990). (+)-N-Allylnormetazocine (NANM)-like discriminative stimulus effects of N-methyl-D-aspartate (NMDA) antagonists. Behavioural Pharmacology, 1(5), 453-458.
Willetts J, Rice A, Balster RL. (+)-N-Allylnormetazocine (NANM)-like Discriminative Stimulus Effects of N-methyl-D-aspartate (NMDA) Antagonists. Behav Pharmacol. 1990;1(5):453-458. PubMed PMID: 11175430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - (+)-N-Allylnormetazocine (NANM)-like discriminative stimulus effects of N-methyl-D-aspartate (NMDA) antagonists. AU - Willetts,J., AU - Rice,A., AU - Balster,R.L., PY - 1990/1/1/pubmed PY - 2001/2/15/medline PY - 1990/1/1/entrez SP - 453 EP - 458 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 1 IS - 5 N2 - The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohepten-5, 10-imine maleate (MK-801), in male Sprague-Dawley rats trained to discriminate 5 mg/kg (+)-N-allyl-normetazocine (NANM) from saline under a standard two-lever fixed-ratio 32 schedule of food reinforcement. (+) - NANM, PCP and MK-801 dose-dependently substituted for the training dose of (+) - NANM in all rats tested. Conversely, NPC 12626 and CPP produced no more than an average of 73% (+) - NANM-lever responding at doses that also reduced response rates by more than 50% of corresponding control response rates. Methohexital also produced an average of 50% (+) - NANM-lever responding at doses that reduced response rates. In addition to supporting a role for the PCP receptor in transducing the discriminative stimulus effects of (+) - NANM, these results lend further evidence for differences in the behavioral effects of competitive and noncompetitive NMDA antagonists. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/11175430/_+__N_Allylnormetazocine__NANM__like_discriminative_stimulus_effects_of_N_methyl_D_aspartate__NMDA__antagonists_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11175430.ui DB - PRIME DP - Unbound Medicine ER -
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