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Insulin response and changes in composition of non-esterified fatty acids in blood plasma of middle-aged men following isoenergetic fatty and carbohydrate breakfasts.
Br J Nutr. 2000 Nov; 84(5):737-45.BJ

Abstract

It was previously shown that a high plasma concentration of non-esterified fatty acids (NEFA) persisted after a fatty breakfast, but not after an isoenergetic carbohydrate breakfast, adversely affecting glucose tolerance. The higher concentration after the fatty breakfast may in part have been a result of different mobilization rates of fatty acids. This factor can be investigated as NEFA mobilized from tissues are monounsaturated to a greater extent than those deposited from a typical meal. Twenty-four middle-aged healthy Caucasian men were given oral glucose tolerance tests (OGTT), and for 28 d isoenergetic breakfasts of similar fat composition but of low (L) or moderate (M) fat content. The composition of NEFA in fasting and postprandial plasma was determined on days 1 and 29. No significant treatment differences in fasting NEFA composition occurred on day 29. During the OGTT and 0-1 h following breakfast there was an increase in plasma long-chain saturated NEFA but a decrease in monounsaturated NEFA (microg/100 microg total NEFA; P<0.001). Between 1 and 3 h following breakfast treatment differences occurred for total saturated and total monounsaturated fatty acids (microg/100 microg total NEFA; P<0.05), expressed as an increase in 18 : 1 and decreases in 16 : 0 and 17 : 0 in treatment M relative to treatment L (P<0.05). Serum insulin attained 35 and 65 mU/l in treatments M and L respectively during this period. Negative correlations were found between 16 : 0 in fasting plasma and both waist:hip circumference (P=0.0009) and insulin response curve area during OGTT (within treatment M, P=0.0001). It is concluded that a normal postprandial insulin response is associated with a rapid change in plasma saturated:monounsaturated NEFA. It is proposed that this change is the result of a variable suppression of fat mobilization, which may partly account for a large difference in postprandial total plasma NEFA between fatty and carbohydrate meals.

Authors+Show Affiliations

NS Research, The Priory, Churchyard, Mildenhall, Suffolk IP28 7EE, UK. david.l.frape@btinternet.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11177189

Citation

Frape, D L., et al. "Insulin Response and Changes in Composition of Non-esterified Fatty Acids in Blood Plasma of Middle-aged Men Following Isoenergetic Fatty and Carbohydrate Breakfasts." The British Journal of Nutrition, vol. 84, no. 5, 2000, pp. 737-45.
Frape DL, Williams NR, Carpenter KL, et al. Insulin response and changes in composition of non-esterified fatty acids in blood plasma of middle-aged men following isoenergetic fatty and carbohydrate breakfasts. Br J Nutr. 2000;84(5):737-45.
Frape, D. L., Williams, N. R., Carpenter, K. L., Freeman, M. A., Palmer, C. R., & Fletcher, R. J. (2000). Insulin response and changes in composition of non-esterified fatty acids in blood plasma of middle-aged men following isoenergetic fatty and carbohydrate breakfasts. The British Journal of Nutrition, 84(5), 737-45.
Frape DL, et al. Insulin Response and Changes in Composition of Non-esterified Fatty Acids in Blood Plasma of Middle-aged Men Following Isoenergetic Fatty and Carbohydrate Breakfasts. Br J Nutr. 2000;84(5):737-45. PubMed PMID: 11177189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin response and changes in composition of non-esterified fatty acids in blood plasma of middle-aged men following isoenergetic fatty and carbohydrate breakfasts. AU - Frape,D L, AU - Williams,N R, AU - Carpenter,K L, AU - Freeman,M A, AU - Palmer,C R, AU - Fletcher,R J, PY - 2001/2/15/pubmed PY - 2001/3/17/medline PY - 2001/2/15/entrez SP - 737 EP - 45 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 84 IS - 5 N2 - It was previously shown that a high plasma concentration of non-esterified fatty acids (NEFA) persisted after a fatty breakfast, but not after an isoenergetic carbohydrate breakfast, adversely affecting glucose tolerance. The higher concentration after the fatty breakfast may in part have been a result of different mobilization rates of fatty acids. This factor can be investigated as NEFA mobilized from tissues are monounsaturated to a greater extent than those deposited from a typical meal. Twenty-four middle-aged healthy Caucasian men were given oral glucose tolerance tests (OGTT), and for 28 d isoenergetic breakfasts of similar fat composition but of low (L) or moderate (M) fat content. The composition of NEFA in fasting and postprandial plasma was determined on days 1 and 29. No significant treatment differences in fasting NEFA composition occurred on day 29. During the OGTT and 0-1 h following breakfast there was an increase in plasma long-chain saturated NEFA but a decrease in monounsaturated NEFA (microg/100 microg total NEFA; P<0.001). Between 1 and 3 h following breakfast treatment differences occurred for total saturated and total monounsaturated fatty acids (microg/100 microg total NEFA; P<0.05), expressed as an increase in 18 : 1 and decreases in 16 : 0 and 17 : 0 in treatment M relative to treatment L (P<0.05). Serum insulin attained 35 and 65 mU/l in treatments M and L respectively during this period. Negative correlations were found between 16 : 0 in fasting plasma and both waist:hip circumference (P=0.0009) and insulin response curve area during OGTT (within treatment M, P=0.0001). It is concluded that a normal postprandial insulin response is associated with a rapid change in plasma saturated:monounsaturated NEFA. It is proposed that this change is the result of a variable suppression of fat mobilization, which may partly account for a large difference in postprandial total plasma NEFA between fatty and carbohydrate meals. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11177189/Insulin_response_and_changes_in_composition_of_non_esterified_fatty_acids_in_blood_plasma_of_middle_aged_men_following_isoenergetic_fatty_and_carbohydrate_breakfasts_ L2 - https://www.cambridge.org/core/product/identifier/S0007114500002105/type/journal_article DB - PRIME DP - Unbound Medicine ER -