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Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women.
Br J Nutr. 2000 Dec; 84(6):839-46.BJ

Abstract

Rye is an important source of plant lignans in Finland. In the present crossover trial we wanted to study the effect of rye bread as part of the usual diet on serum and urine enterolactone (ENL) concentrations in healthy volunteers. Eighteen men aged 43 (sem 2.0) years and twenty-one women aged 43 (sem 1.6) years consumed wholemeal rye bread and white wheat bread in random order for 4 weeks. The bread periods were separated by a 4 week wash-out period. The breads provided at least 20% of the daily energy intake. The mean intakes of rye bread were 219 (sem 14.6) and 162 (sem 5.3) g/d and those of wheat bread were 200 (sem 9.6) and 153 (sem 5.8) g/d for men and women respectively. Blood samples were collected from all subjects and three 24 h urine samples were collected from ten men and twelve women at the end of both bread periods for the determination of serum concentration and urinary excretion of ENL. The mean serum ENL concentrations in both men and women at the beginning of baseline period and at the end of the rye-bread period remained constant and were significantly higher than those at the end of the wheat-bread period. Correspondingly, daily urinary ENL excretion increased significantly during the rye-bread period compared with the wheat-bread period and was 5- and 10-fold higher in men and women respectively in comparison with the amount of plant lignan precursors measured in the rye bread. These data indicate the presence of other precursors for ENL in rye which are not detected by the current method of measuring plant lignans in food. The possible role of fibre in enhancement of the formation of mammalian lignans from their plant precursors in the gut also remains to be determined.

Authors+Show Affiliations

University of Kuopio, Department of Clinical Nutrition, PO Box 1627, FIN-70211 Kuopio, Finland. katri.juntunen@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11177200

Citation

Juntunen, K S., et al. "Consumption of Wholemeal Rye Bread Increases Serum Concentrations and Urinary Excretion of Enterolactone Compared With Consumption of White Wheat Bread in Healthy Finnish Men and Women." The British Journal of Nutrition, vol. 84, no. 6, 2000, pp. 839-46.
Juntunen KS, Mazur WM, Liukkonen KH, et al. Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women. Br J Nutr. 2000;84(6):839-46.
Juntunen, K. S., Mazur, W. M., Liukkonen, K. H., Uehara, M., Poutanen, K. S., Adlercreutz, H. C., & Mykkänen, H. M. (2000). Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women. The British Journal of Nutrition, 84(6), 839-46.
Juntunen KS, et al. Consumption of Wholemeal Rye Bread Increases Serum Concentrations and Urinary Excretion of Enterolactone Compared With Consumption of White Wheat Bread in Healthy Finnish Men and Women. Br J Nutr. 2000;84(6):839-46. PubMed PMID: 11177200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women. AU - Juntunen,K S, AU - Mazur,W M, AU - Liukkonen,K H, AU - Uehara,M, AU - Poutanen,K S, AU - Adlercreutz,H C, AU - Mykkänen,H M, PY - 2001/2/15/pubmed PY - 2001/3/7/medline PY - 2001/2/15/entrez SP - 839 EP - 46 JF - The British journal of nutrition JO - Br J Nutr VL - 84 IS - 6 N2 - Rye is an important source of plant lignans in Finland. In the present crossover trial we wanted to study the effect of rye bread as part of the usual diet on serum and urine enterolactone (ENL) concentrations in healthy volunteers. Eighteen men aged 43 (sem 2.0) years and twenty-one women aged 43 (sem 1.6) years consumed wholemeal rye bread and white wheat bread in random order for 4 weeks. The bread periods were separated by a 4 week wash-out period. The breads provided at least 20% of the daily energy intake. The mean intakes of rye bread were 219 (sem 14.6) and 162 (sem 5.3) g/d and those of wheat bread were 200 (sem 9.6) and 153 (sem 5.8) g/d for men and women respectively. Blood samples were collected from all subjects and three 24 h urine samples were collected from ten men and twelve women at the end of both bread periods for the determination of serum concentration and urinary excretion of ENL. The mean serum ENL concentrations in both men and women at the beginning of baseline period and at the end of the rye-bread period remained constant and were significantly higher than those at the end of the wheat-bread period. Correspondingly, daily urinary ENL excretion increased significantly during the rye-bread period compared with the wheat-bread period and was 5- and 10-fold higher in men and women respectively in comparison with the amount of plant lignan precursors measured in the rye bread. These data indicate the presence of other precursors for ENL in rye which are not detected by the current method of measuring plant lignans in food. The possible role of fibre in enhancement of the formation of mammalian lignans from their plant precursors in the gut also remains to be determined. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11177200/Consumption_of_wholemeal_rye_bread_increases_serum_concentrations_and_urinary_excretion_of_enterolactone_compared_with_consumption_of_white_wheat_bread_in_healthy_Finnish_men_and_women_ L2 - https://www.cambridge.org/core/product/identifier/S0007114500002622/type/journal_article DB - PRIME DP - Unbound Medicine ER -