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Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice.
Br J Nutr 2000; 84(6):911-7BJ

Abstract

The aim of this present study was to investigate the effect of amount and degree of oxidation of dietary oil on type 2 T-helper cell (TH)-related immune responses. Four groups of BALB/c mice were fed either 50 g soyabean oil/kg (50-S), 50 g oxidized oil/kg (50-O), 150 g soyabean oil/kg (150-S) or 150 g oxidized oil/kg (150-O). After 14 weeks consuming the experimental diets, the mice were immunized with ovalbumin (OVA) plus Al and antigen-specific immunoglobulin (Ig)E, IgG1 and IgG2a, inflammatory mediators such as prostaglandin (PG) E2 and leukotriene (LT)B4 were determined. Higher hepatic microsomal cytochrome P450 was noted in mice fed 150 g oxidized oil/kg compared with those of other groups. OVA-specific IgG1 and IgE were higher in mice fed 150 g oxidized oil/kg compared with those of the other groups. The data suggested the interleukin (IL)-4: interferon (IFN)-gamma ratio was higher in mice fed 50 g dietary oxidized oil/kg compared with that of the 50-S group. The IL-5:IFN-gamma ratios were higher in the 150-S and 150-O groups than in the 50-S and 50-O groups. PGE2 and LTB4 produced by macrophages stimulated by lipopolysaccharide were highest in mice in the 150 g oxidized oil/kg group. The data suggested that an increased intake of oxidized oil might exert an unfavourable effect on the TH2 response involved in allergic disease.

Authors+Show Affiliations

Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, College of Agriculture, National Taiwan University, Taipei, Taiwan 10764, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11177209

Citation

Lin, B F., et al. "Dietary Oxidized Oil Influences the Levels of Type 2 T-helper Cell-related Antibody and Inflammatory Mediators in Mice." The British Journal of Nutrition, vol. 84, no. 6, 2000, pp. 911-7.
Lin BF, Lai CC, Lin KW, et al. Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice. Br J Nutr. 2000;84(6):911-7.
Lin, B. F., Lai, C. C., Lin, K. W., & Chiang, B. L. (2000). Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice. The British Journal of Nutrition, 84(6), pp. 911-7.
Lin BF, et al. Dietary Oxidized Oil Influences the Levels of Type 2 T-helper Cell-related Antibody and Inflammatory Mediators in Mice. Br J Nutr. 2000;84(6):911-7. PubMed PMID: 11177209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice. AU - Lin,B F, AU - Lai,C C, AU - Lin,K W, AU - Chiang,B L, PY - 2001/2/15/pubmed PY - 2001/3/7/medline PY - 2001/2/15/entrez SP - 911 EP - 7 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 84 IS - 6 N2 - The aim of this present study was to investigate the effect of amount and degree of oxidation of dietary oil on type 2 T-helper cell (TH)-related immune responses. Four groups of BALB/c mice were fed either 50 g soyabean oil/kg (50-S), 50 g oxidized oil/kg (50-O), 150 g soyabean oil/kg (150-S) or 150 g oxidized oil/kg (150-O). After 14 weeks consuming the experimental diets, the mice were immunized with ovalbumin (OVA) plus Al and antigen-specific immunoglobulin (Ig)E, IgG1 and IgG2a, inflammatory mediators such as prostaglandin (PG) E2 and leukotriene (LT)B4 were determined. Higher hepatic microsomal cytochrome P450 was noted in mice fed 150 g oxidized oil/kg compared with those of other groups. OVA-specific IgG1 and IgE were higher in mice fed 150 g oxidized oil/kg compared with those of the other groups. The data suggested the interleukin (IL)-4: interferon (IFN)-gamma ratio was higher in mice fed 50 g dietary oxidized oil/kg compared with that of the 50-S group. The IL-5:IFN-gamma ratios were higher in the 150-S and 150-O groups than in the 50-S and 50-O groups. PGE2 and LTB4 produced by macrophages stimulated by lipopolysaccharide were highest in mice in the 150 g oxidized oil/kg group. The data suggested that an increased intake of oxidized oil might exert an unfavourable effect on the TH2 response involved in allergic disease. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11177209/Dietary_oxidized_oil_influences_the_levels_of_type_2_T_helper_cell_related_antibody_and_inflammatory_mediators_in_mice_ L2 - https://www.cambridge.org/core/product/identifier/S0007114500002713/type/journal_article DB - PRIME DP - Unbound Medicine ER -