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The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy.
Bull Exp Biol Med. 2000 Oct; 130(10):986-90.BE

Abstract

alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy. The aim of the present study was to evaluate the function of nitric oxide (NO) and stress proteins (HSP72) in insulin-dependent diabetes complicated by polyneuropathy and possible contribution of these systems to the therapeutic effects of alpha-lipoic acid. Plasma content of nitrites and nitrates in diabetic patients was almost 2-fold below the normal. The treatment with alpha-lipoic acid completely normalized the plasma content of these stable NO metabolites. The majority of patients had also low level of HSP72. Positive clinical effects of alpha-lipoic acid were accompanied by normalization of HSP72 synthesis. Thus, activation of the NO and HSP protective systems is involved in the therapeutic effect of alpha-lipoic acid in diabetic patients (type 1 diabetes mellitus) with polyneuropathy.

Authors+Show Affiliations

Department of Endocrinology and Diabetology, Russian Medical Academy of Postgraduate Education, Moscow.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11177301

Citation

Strokov, I A., et al. "The Function of Endogenous Protective Systems in Patients With Insulin-dependent Diabetes Mellitus and Polyneuropathy: Effect of Antioxidant Therapy." Bulletin of Experimental Biology and Medicine, vol. 130, no. 10, 2000, pp. 986-90.
Strokov IA, Manukhina EB, Bakhtina LY, et al. The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy. Bull Exp Biol Med. 2000;130(10):986-90.
Strokov, I. A., Manukhina, E. B., Bakhtina, L. Y., Malyshev, I. Y., Zoloev, G. K., Kazikhanova, S. I., & Ametov, A. S. (2000). The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy. Bulletin of Experimental Biology and Medicine, 130(10), 986-90.
Strokov IA, et al. The Function of Endogenous Protective Systems in Patients With Insulin-dependent Diabetes Mellitus and Polyneuropathy: Effect of Antioxidant Therapy. Bull Exp Biol Med. 2000;130(10):986-90. PubMed PMID: 11177301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy. AU - Strokov,I A, AU - Manukhina,E B, AU - Bakhtina,L Y, AU - Malyshev,I Y, AU - Zoloev,G K, AU - Kazikhanova,S I, AU - Ametov,A S, PY - 2000/09/18/received PY - 2001/2/15/pubmed PY - 2001/8/3/medline PY - 2001/2/15/entrez SP - 986 EP - 90 JF - Bulletin of experimental biology and medicine JO - Bull Exp Biol Med VL - 130 IS - 10 N2 - alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy. The aim of the present study was to evaluate the function of nitric oxide (NO) and stress proteins (HSP72) in insulin-dependent diabetes complicated by polyneuropathy and possible contribution of these systems to the therapeutic effects of alpha-lipoic acid. Plasma content of nitrites and nitrates in diabetic patients was almost 2-fold below the normal. The treatment with alpha-lipoic acid completely normalized the plasma content of these stable NO metabolites. The majority of patients had also low level of HSP72. Positive clinical effects of alpha-lipoic acid were accompanied by normalization of HSP72 synthesis. Thus, activation of the NO and HSP protective systems is involved in the therapeutic effect of alpha-lipoic acid in diabetic patients (type 1 diabetes mellitus) with polyneuropathy. SN - 0007-4888 UR - https://www.unboundmedicine.com/medline/citation/11177301/The_function_of_endogenous_protective_systems_in_patients_with_insulin_dependent_diabetes_mellitus_and_polyneuropathy:_effect_of_antioxidant_therapy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11177301.ui DB - PRIME DP - Unbound Medicine ER -