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Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage.
Osteoarthritis Cartilage. 2001 Jan; 9(1):49-55.OC

Abstract

OBJECTIVE

To investigate the relationship between biochemical markers in the synovial fluid of osteoarthritic and contralateral equine joints and gross articular cartilage pathology.

DESIGN

Twenty-two horses underwent bilateral arthroscopy of their carpal or metacarpophalangeal joints following recent onset lameness. The degree of cartilage damage in each joint was scored and synovial fluid, from both the clinically affected and the contralateral joint, was collected. Bone specific alkaline phosphatase (BAP), 5D4 epitope of keratan sulphate (KS), total glycosaminoglycans (GAG) and hyaluronan (HA) were measured.

RESULTS

The mean age of the horses was 4.1 years and the maximum duration of lameness was three months. Joints examined were midcarpal, antebrachiocarpal and metacarpophalangeal. The median concentration (semi-interquartile range) of BAP was significantly higher in the clinically active joint than in the contralateral joint, 21.75 (6.22) vs. 12.35 (4.07) units, while the other biomarkers measured were significantly lower in the clinically active joint than in the contralateral joint, i.e. KS 8.79 (1.96) microg/ml vs. 16.39 (5.65) microg/ml, KS:GAG ratio 0.19 (0.04) vs. 0.31 (0.10) and HA 741.6 (222) microg/ml vs. 1061.75 (325) microg/ml. BAP was positively (R=0.57), and KS (R=-0.57) and KS:GAG ratio (R=-0.49) were negatively correlated to the degree of cartilage damage within the joint.

CONCLUSION

The correlation between articular cartilage damage and synovial fluid BAP and KS imparts validity to their potential use as non-invasive diagnostic aids in equine osteoarthritis (OA). The positive correlation between BAP and cartilage damage suggests that there is a link between bone turnover and cartilage damage in OA.

Authors+Show Affiliations

Dept of Clinical Veterinary Science, University of Bristol, UK. C.J.Fuller@bris.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11178947

Citation

Fuller, C J., et al. "Cross-sectional Comparison of Synovial Fluid Biochemical Markers in Equine Osteoarthritis and the Correlation of These Markers With Articular Cartilage Damage." Osteoarthritis and Cartilage, vol. 9, no. 1, 2001, pp. 49-55.
Fuller CJ, Barr AR, Sharif M, et al. Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage. Osteoarthr Cartil. 2001;9(1):49-55.
Fuller, C. J., Barr, A. R., Sharif, M., & Dieppe, P. A. (2001). Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage. Osteoarthritis and Cartilage, 9(1), 49-55.
Fuller CJ, et al. Cross-sectional Comparison of Synovial Fluid Biochemical Markers in Equine Osteoarthritis and the Correlation of These Markers With Articular Cartilage Damage. Osteoarthr Cartil. 2001;9(1):49-55. PubMed PMID: 11178947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage. AU - Fuller,C J, AU - Barr,A R, AU - Sharif,M, AU - Dieppe,P A, PY - 2001/2/17/pubmed PY - 2001/4/21/medline PY - 2001/2/17/entrez SP - 49 EP - 55 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 9 IS - 1 N2 - OBJECTIVE: To investigate the relationship between biochemical markers in the synovial fluid of osteoarthritic and contralateral equine joints and gross articular cartilage pathology. DESIGN: Twenty-two horses underwent bilateral arthroscopy of their carpal or metacarpophalangeal joints following recent onset lameness. The degree of cartilage damage in each joint was scored and synovial fluid, from both the clinically affected and the contralateral joint, was collected. Bone specific alkaline phosphatase (BAP), 5D4 epitope of keratan sulphate (KS), total glycosaminoglycans (GAG) and hyaluronan (HA) were measured. RESULTS: The mean age of the horses was 4.1 years and the maximum duration of lameness was three months. Joints examined were midcarpal, antebrachiocarpal and metacarpophalangeal. The median concentration (semi-interquartile range) of BAP was significantly higher in the clinically active joint than in the contralateral joint, 21.75 (6.22) vs. 12.35 (4.07) units, while the other biomarkers measured were significantly lower in the clinically active joint than in the contralateral joint, i.e. KS 8.79 (1.96) microg/ml vs. 16.39 (5.65) microg/ml, KS:GAG ratio 0.19 (0.04) vs. 0.31 (0.10) and HA 741.6 (222) microg/ml vs. 1061.75 (325) microg/ml. BAP was positively (R=0.57), and KS (R=-0.57) and KS:GAG ratio (R=-0.49) were negatively correlated to the degree of cartilage damage within the joint. CONCLUSION: The correlation between articular cartilage damage and synovial fluid BAP and KS imparts validity to their potential use as non-invasive diagnostic aids in equine osteoarthritis (OA). The positive correlation between BAP and cartilage damage suggests that there is a link between bone turnover and cartilage damage in OA. SN - 1063-4584 UR - https://www.unboundmedicine.com/medline/citation/11178947/Cross_sectional_comparison_of_synovial_fluid_biochemical_markers_in_equine_osteoarthritis_and_the_correlation_of_these_markers_with_articular_cartilage_damage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(00)90349-2 DB - PRIME DP - Unbound Medicine ER -