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Antidermatophytic properties of extracts from the leaves of Aristolochia paucinervis Pomel.
Phytother Res. 2001 Feb; 15(1):79-81.PR

Abstract

Several fractions of a methanol extract from the leaves of Aristolochia paucinervis Pomel (Aristolochiaceae) were screened for their antidermatophytic efficiency against different human pathogenic fungi responsible for tinea and other skin infections. The antifungal study was carried out by the macrodilution agar method and the results showed that, with the exception of the aqueous fraction, all the fractions exhibited antifungal activities against the dermatophytic fungi tested. The hexane fraction was found to be the most effective (MIC range: 64-2048 microg/mL), whereas the butanol fraction was the least active (MIC range: 1024 microg/mL to more than 2048 microg/mL). The most susceptible fungi were Epidermophyton floccosum and Trichophyton violaceum in contrast to Trichophyton mentagrophytes and Trychophyton rubrum which were less sensitive to the fractions tested. The effects were compared with those of ketoconazole, amphotericin B and griseofulvin, for which MIC ranges were, respectively, 0.12-4 microg/mL, 0.5-4 microg/mL and 0.5-2 microg/mL.

Authors+Show Affiliations

Gadhi CA
Laboratoire de Phytochimie des Plantes Médicinales, Faculté des Sciences-Semlalia, Université Cadi Ayyad, B.P. S/15, Marrakech 40000, Morocco. radi.gadhi@iam.net.ma
Benharref A
No affiliation info available
Jana M
No affiliation info available
Basile AM
No affiliation info available
Contet-Audonneau N
No affiliation info available
Fortier B
No affiliation info available

MeSH

Antifungal AgentsArthrodermataceaeDermatomycosesHumansMicrobial Sensitivity TestsPlant ExtractsPlant LeavesPlants, Medicinal

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11180530

Citation

Gadhi, C A., et al. "Antidermatophytic Properties of Extracts From the Leaves of Aristolochia Paucinervis Pomel." Phytotherapy Research : PTR, vol. 15, no. 1, 2001, pp. 79-81.
Gadhi CA, Benharref A, Jana M, et al. Antidermatophytic properties of extracts from the leaves of Aristolochia paucinervis Pomel. Phytother Res. 2001;15(1):79-81.
Gadhi, C. A., Benharref, A., Jana, M., Basile, A. M., Contet-Audonneau, N., & Fortier, B. (2001). Antidermatophytic properties of extracts from the leaves of Aristolochia paucinervis Pomel. Phytotherapy Research : PTR, 15(1), 79-81.
Gadhi CA, et al. Antidermatophytic Properties of Extracts From the Leaves of Aristolochia Paucinervis Pomel. Phytother Res. 2001;15(1):79-81. PubMed PMID: 11180530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidermatophytic properties of extracts from the leaves of Aristolochia paucinervis Pomel. AU - Gadhi,C A, AU - Benharref,A, AU - Jana,M, AU - Basile,A M, AU - Contet-Audonneau,N, AU - Fortier,B, PY - 2001/2/17/pubmed PY - 2001/5/22/medline PY - 2001/2/17/entrez SP - 79 EP - 81 JF - Phytotherapy research : PTR JO - Phytother Res VL - 15 IS - 1 N2 - Several fractions of a methanol extract from the leaves of Aristolochia paucinervis Pomel (Aristolochiaceae) were screened for their antidermatophytic efficiency against different human pathogenic fungi responsible for tinea and other skin infections. The antifungal study was carried out by the macrodilution agar method and the results showed that, with the exception of the aqueous fraction, all the fractions exhibited antifungal activities against the dermatophytic fungi tested. The hexane fraction was found to be the most effective (MIC range: 64-2048 microg/mL), whereas the butanol fraction was the least active (MIC range: 1024 microg/mL to more than 2048 microg/mL). The most susceptible fungi were Epidermophyton floccosum and Trichophyton violaceum in contrast to Trichophyton mentagrophytes and Trychophyton rubrum which were less sensitive to the fractions tested. The effects were compared with those of ketoconazole, amphotericin B and griseofulvin, for which MIC ranges were, respectively, 0.12-4 microg/mL, 0.5-4 microg/mL and 0.5-2 microg/mL. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/11180530/Antidermatophytic_properties_of_extracts_from_the_leaves_of_Aristolochia_paucinervis_Pomel_ DB - PRIME DP - Unbound Medicine ER -