Tags

Type your tag names separated by a space and hit enter

Ambulatory ECG and analysis of heart rate variability in Parkinson's disease.
J Neurol Neurosurg Psychiatry. 2001 Mar; 70(3):305-10.JN

Abstract

OBJECTIVES

Cardiovascular reflex tests have shown both sympathetic and parasympathetic failure in Parkinson's disease. These tests, however, describe the autonomic responses during a restricted time period and have great individual variability, providing a limited view of the autonomic cardiac control mechanisms. Thus, they do not reflect tonic autonomic regulation. The aim was to examine tonic autonomic cardiovascular regulation in untreated patients with Parkinson's disease.

METHODS

24 Hour ambulatory ECG was recorded in 54 untreated patients with Parkinson's disease and 47 age matched healthy subjects. In addition to the traditional spectral (very low frequency, VLF; low frequency, LF; high frequency, HF) and non-spectral components of heart rate variability, instantaneous beat to beat variability (SD1) and long term continuous variability (SD2) derived from Poincaré plots, and the slope of the power law relation were analysed.

RESULTS

All spectral components (p<0.01) and the slope of the power-law relation (p<0.01) were lower in the patients with Parkinson's disease than in the control subjects. The Unified Parkinson's disease rating scale total and motor scores had a negative correlation with VLF and LF power spectrum values and the power law relation slopes. Patients with mild hypokinesia had higher HF values than patients with more severe hypokinesia. Tremor and rigidity were not associated with the HR variability parameters.

CONCLUSIONS

Parkinson's disease causes dysfunction of the diurnal autonomic cardiovascular regulation as demonstrated by the spectral measures of heart rate variability and the slope of the power law relation. This dysfunction seems to be more profound in patients with more severe Parkinson's disease.

Authors+Show Affiliations

Department of Neurology, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland. Tarja.Haapaniemi@oulu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11181850

Citation

Haapaniemi, T H., et al. "Ambulatory ECG and Analysis of Heart Rate Variability in Parkinson's Disease." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 70, no. 3, 2001, pp. 305-10.
Haapaniemi TH, Pursiainen V, Korpelainen JT, et al. Ambulatory ECG and analysis of heart rate variability in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2001;70(3):305-10.
Haapaniemi, T. H., Pursiainen, V., Korpelainen, J. T., Huikuri, H. V., Sotaniemi, K. A., & Myllylä, V. V. (2001). Ambulatory ECG and analysis of heart rate variability in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 70(3), 305-10.
Haapaniemi TH, et al. Ambulatory ECG and Analysis of Heart Rate Variability in Parkinson's Disease. J Neurol Neurosurg Psychiatry. 2001;70(3):305-10. PubMed PMID: 11181850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ambulatory ECG and analysis of heart rate variability in Parkinson's disease. AU - Haapaniemi,T H, AU - Pursiainen,V, AU - Korpelainen,J T, AU - Huikuri,H V, AU - Sotaniemi,K A, AU - Myllylä,V V, PY - 2001/2/22/pubmed PY - 2001/4/17/medline PY - 2001/2/22/entrez SP - 305 EP - 10 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 70 IS - 3 N2 - OBJECTIVES: Cardiovascular reflex tests have shown both sympathetic and parasympathetic failure in Parkinson's disease. These tests, however, describe the autonomic responses during a restricted time period and have great individual variability, providing a limited view of the autonomic cardiac control mechanisms. Thus, they do not reflect tonic autonomic regulation. The aim was to examine tonic autonomic cardiovascular regulation in untreated patients with Parkinson's disease. METHODS: 24 Hour ambulatory ECG was recorded in 54 untreated patients with Parkinson's disease and 47 age matched healthy subjects. In addition to the traditional spectral (very low frequency, VLF; low frequency, LF; high frequency, HF) and non-spectral components of heart rate variability, instantaneous beat to beat variability (SD1) and long term continuous variability (SD2) derived from Poincaré plots, and the slope of the power law relation were analysed. RESULTS: All spectral components (p<0.01) and the slope of the power-law relation (p<0.01) were lower in the patients with Parkinson's disease than in the control subjects. The Unified Parkinson's disease rating scale total and motor scores had a negative correlation with VLF and LF power spectrum values and the power law relation slopes. Patients with mild hypokinesia had higher HF values than patients with more severe hypokinesia. Tremor and rigidity were not associated with the HR variability parameters. CONCLUSIONS: Parkinson's disease causes dysfunction of the diurnal autonomic cardiovascular regulation as demonstrated by the spectral measures of heart rate variability and the slope of the power law relation. This dysfunction seems to be more profound in patients with more severe Parkinson's disease. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/11181850/Ambulatory_ECG_and_analysis_of_heart_rate_variability_in_Parkinson's_disease_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&amp;pmid=11181850 DB - PRIME DP - Unbound Medicine ER -