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Comparison of azithromycin leukocyte disposition in healthy volunteers and volunteers with AIDS.
Int J Antimicrob Agents. 2000 Sep; 16(1):37-43.IJ

Abstract

Azithromycin, has been proved to be effective in the treatment and prophylaxis of a wide variety of infections. While the penetration of azithromycin into a number of types of mammalian cells has been well characterized, the influence of HIV infection on the intracellular disposition of this agent has not been studied. We therefore studied the disposition of azithromycin in polymorphonuclear (PMN) and mononuclear (MONO) leukocytes from six healthy volunteers and six volunteers with AIDS. After oral administration of a single 1200-mg dose of azithromycin (two 600-mg tablets), blood samples were collected over 6 days and intracellular azithromycin concentrations in MONOs and PMNs were measured. Analysis of the intracellular pharmacokinetics revealed an apparent difference in the MONO and PMN profile; this profile was similar for both groups. Intracellular concentrations of azithromycin remained high throughout the study period. Furthermore, no statistically significant differences in the intracellular area under the curve (11309+/-2543 vs. 16650+/-6254 for PMN; 14180+/-3802 vs. 21211+/-10001 for MONO) were observed between the healthy and AIDS populations, respectively. Our data confirm the extensive uptake of azithromycin by white blood cells both in healthy volunteers and in AIDS patients.

Authors+Show Affiliations

Department of Pharmacy Research, Hartford Hospital, CT 06102, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11185411

Citation

McNabb, J, et al. "Comparison of Azithromycin Leukocyte Disposition in Healthy Volunteers and Volunteers With AIDS." International Journal of Antimicrobial Agents, vol. 16, no. 1, 2000, pp. 37-43.
McNabb J, Owens RC, Xuan D, et al. Comparison of azithromycin leukocyte disposition in healthy volunteers and volunteers with AIDS. Int J Antimicrob Agents. 2000;16(1):37-43.
McNabb, J., Owens, R. C., Xuan, D., Quintiliani, R., Nightingale, C. H., & Nicolau, D. P. (2000). Comparison of azithromycin leukocyte disposition in healthy volunteers and volunteers with AIDS. International Journal of Antimicrobial Agents, 16(1), 37-43.
McNabb J, et al. Comparison of Azithromycin Leukocyte Disposition in Healthy Volunteers and Volunteers With AIDS. Int J Antimicrob Agents. 2000;16(1):37-43. PubMed PMID: 11185411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of azithromycin leukocyte disposition in healthy volunteers and volunteers with AIDS. AU - McNabb,J, AU - Owens,R C, AU - Xuan,D, AU - Quintiliani,R, AU - Nightingale,C H, AU - Nicolau,D P, PY - 2001/2/24/pubmed PY - 2001/2/28/medline PY - 2001/2/24/entrez SP - 37 EP - 43 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 16 IS - 1 N2 - Azithromycin, has been proved to be effective in the treatment and prophylaxis of a wide variety of infections. While the penetration of azithromycin into a number of types of mammalian cells has been well characterized, the influence of HIV infection on the intracellular disposition of this agent has not been studied. We therefore studied the disposition of azithromycin in polymorphonuclear (PMN) and mononuclear (MONO) leukocytes from six healthy volunteers and six volunteers with AIDS. After oral administration of a single 1200-mg dose of azithromycin (two 600-mg tablets), blood samples were collected over 6 days and intracellular azithromycin concentrations in MONOs and PMNs were measured. Analysis of the intracellular pharmacokinetics revealed an apparent difference in the MONO and PMN profile; this profile was similar for both groups. Intracellular concentrations of azithromycin remained high throughout the study period. Furthermore, no statistically significant differences in the intracellular area under the curve (11309+/-2543 vs. 16650+/-6254 for PMN; 14180+/-3802 vs. 21211+/-10001 for MONO) were observed between the healthy and AIDS populations, respectively. Our data confirm the extensive uptake of azithromycin by white blood cells both in healthy volunteers and in AIDS patients. SN - 0924-8579 UR - https://www.unboundmedicine.com/medline/citation/11185411/Comparison_of_azithromycin_leukocyte_disposition_in_healthy_volunteers_and_volunteers_with_AIDS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(00)00201-6 DB - PRIME DP - Unbound Medicine ER -