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Loss of transferase enzyme activity of transfused erythrocytes in galactosemia.
South Med J. 1975 Mar; 68(3):301-2.SM

Abstract

Rapid loss of erythrocyte galactose-1-phosphate uridyl transferase in hemolysates from an infant 26 days after transfusion led to investigation of the possiblity of an unstable enzyme or other variant of galactosemia. However, the child was found to have the classic type of galactosemia. The seeming transferase instability was attributable to loss of enzyme activity in hemolysates from blood containg aged, transfused cells, the source of the enzyme. Thus when transfusion is necessary, transferase assay for diagnosis of the enzyme deficiency before transfusion avoids confusion attributable to the enzyme supplied in the transfused cells.

Authors

Schwartz RP
No affiliation info available
Roesel RA
No affiliation info available
Blankenship PR
No affiliation info available
Hall WK
No affiliation info available

MeSH

AdultErythrocytesExchange Transfusion, Whole BloodFemaleGalactosemiasHemolysisHumansInfantMaleNucleotidyltransferases

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1118770

Citation

Schwartz, R P., et al. "Loss of Transferase Enzyme Activity of Transfused Erythrocytes in Galactosemia." Southern Medical Journal, vol. 68, no. 3, 1975, pp. 301-2.
Schwartz RP, Roesel RA, Blankenship PR, et al. Loss of transferase enzyme activity of transfused erythrocytes in galactosemia. South Med J. 1975;68(3):301-2.
Schwartz, R. P., Roesel, R. A., Blankenship, P. R., & Hall, W. K. (1975). Loss of transferase enzyme activity of transfused erythrocytes in galactosemia. Southern Medical Journal, 68(3), 301-2.
Schwartz RP, et al. Loss of Transferase Enzyme Activity of Transfused Erythrocytes in Galactosemia. South Med J. 1975;68(3):301-2. PubMed PMID: 1118770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Loss of transferase enzyme activity of transfused erythrocytes in galactosemia. AU - Schwartz,R P, AU - Roesel,R A, AU - Blankenship,P R, AU - Hall,W K, PY - 1975/3/1/pubmed PY - 1975/3/1/medline PY - 1975/3/1/entrez SP - 301 EP - 2 JF - Southern medical journal JO - South Med J VL - 68 IS - 3 N2 - Rapid loss of erythrocyte galactose-1-phosphate uridyl transferase in hemolysates from an infant 26 days after transfusion led to investigation of the possiblity of an unstable enzyme or other variant of galactosemia. However, the child was found to have the classic type of galactosemia. The seeming transferase instability was attributable to loss of enzyme activity in hemolysates from blood containg aged, transfused cells, the source of the enzyme. Thus when transfusion is necessary, transferase assay for diagnosis of the enzyme deficiency before transfusion avoids confusion attributable to the enzyme supplied in the transfused cells. SN - 0038-4348 UR - https://www.unboundmedicine.com/medline/citation/1118770/Loss_of_transferase_enzyme_activity_of_transfused_erythrocytes_in_galactosemia_ DB - PRIME DP - Unbound Medicine ER -