Tags

Type your tag names separated by a space and hit enter

[Phytoestrogens].
Nihon Rinsho 2000; 58(12):2434-8NR

Abstract

Epidemiological studies revealed that foodstuffs, in particular, soy foods containing isoflavonoid phytoestrogens may reduce the risk of some hormone-dependent disease such as not only postmenopausal symptoms but also certain(breast, prostate and colon) cancers and cardiovascular disease. This review introduces the metabolism of soybean isoflavonoids by human intestinal bacteria and the binding and gene-expression activity of the metabolites towards the human estrogen receptor(hER) alpha and beta. The dietary isoflavones(daidzin and genistin) in soybean were metabolized to equol and dihydrogenistein via daidzein and genistein, respectively. The metabolites bind more strongly to hER beta than hER alpha. The binding affinity of genistein is comparable that of 17 beta-estradiol. Equol induces transcription most strongly both with hER beta and hER alpha.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, Fukuoka University.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

11187733

Citation

Kinjo, J. "[Phytoestrogens]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 58, no. 12, 2000, pp. 2434-8.
Kinjo J. [Phytoestrogens]. Nippon Rinsho. 2000;58(12):2434-8.
Kinjo, J. (2000). [Phytoestrogens]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 58(12), pp. 2434-8.
Kinjo J. [Phytoestrogens]. Nippon Rinsho. 2000;58(12):2434-8. PubMed PMID: 11187733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Phytoestrogens]. A1 - Kinjo,J, PY - 2001/2/24/pubmed PY - 2001/3/7/medline PY - 2001/2/24/entrez SP - 2434 EP - 8 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nippon Rinsho VL - 58 IS - 12 N2 - Epidemiological studies revealed that foodstuffs, in particular, soy foods containing isoflavonoid phytoestrogens may reduce the risk of some hormone-dependent disease such as not only postmenopausal symptoms but also certain(breast, prostate and colon) cancers and cardiovascular disease. This review introduces the metabolism of soybean isoflavonoids by human intestinal bacteria and the binding and gene-expression activity of the metabolites towards the human estrogen receptor(hER) alpha and beta. The dietary isoflavones(daidzin and genistin) in soybean were metabolized to equol and dihydrogenistein via daidzein and genistein, respectively. The metabolites bind more strongly to hER beta than hER alpha. The binding affinity of genistein is comparable that of 17 beta-estradiol. Equol induces transcription most strongly both with hER beta and hER alpha. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/11187733/[Phytoestrogens]_ L2 - https://www.lens.org/lens/search?q=citation_id:11187733 DB - PRIME DP - Unbound Medicine ER -