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[ATP receptors in pain].
Nihon Yakurigaku Zasshi 2000; 116(6):343-50NY

Abstract

Extracellular ATP has been known to activate sensory neurons via the ATP-gated ion channels P2X receptors, leading to the proposal that the P2X receptors may play a role in signal transduction of pain from the peripheral site to the spinal cord in vivo. P2X3 receptors are expressed in capsaicin-sensitive small-sized dorsal root ganglion (DRG) neurons, and they are involved in the generation of rapidly desensitizing inward current and evoking nocifensive behavior and thermal hyperalgesia. Heteromeric P2X2/3 (P2X2 and P2X3) receptor is expressed in capsaicin-insensitive primary afferent fibers, and its activation leads to the generation of slow desensitizing currents and induction of mechanical allodynia. In addition, accumulating information suggests the involvement of G protein-coupled ATP receptors in the modulation of the generation and transmission of pain.

Authors+Show Affiliations

Neuropharmacology Section, Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

11188502

Citation

Tsuda, M, et al. "[ATP Receptors in Pain]." Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica, vol. 116, no. 6, 2000, pp. 343-50.
Tsuda M, Koizumi S, Inoue K. [ATP receptors in pain]. Nippon Yakurigaku Zasshi. 2000;116(6):343-50.
Tsuda, M., Koizumi, S., & Inoue, K. (2000). [ATP receptors in pain]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica, 116(6), pp. 343-50.
Tsuda M, Koizumi S, Inoue K. [ATP Receptors in Pain]. Nippon Yakurigaku Zasshi. 2000;116(6):343-50. PubMed PMID: 11188502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [ATP receptors in pain]. AU - Tsuda,M, AU - Koizumi,S, AU - Inoue,K, PY - 2001/2/24/pubmed PY - 2001/3/7/medline PY - 2001/2/24/entrez SP - 343 EP - 50 JF - Nihon yakurigaku zasshi. Folia pharmacologica Japonica JO - Nippon Yakurigaku Zasshi VL - 116 IS - 6 N2 - Extracellular ATP has been known to activate sensory neurons via the ATP-gated ion channels P2X receptors, leading to the proposal that the P2X receptors may play a role in signal transduction of pain from the peripheral site to the spinal cord in vivo. P2X3 receptors are expressed in capsaicin-sensitive small-sized dorsal root ganglion (DRG) neurons, and they are involved in the generation of rapidly desensitizing inward current and evoking nocifensive behavior and thermal hyperalgesia. Heteromeric P2X2/3 (P2X2 and P2X3) receptor is expressed in capsaicin-insensitive primary afferent fibers, and its activation leads to the generation of slow desensitizing currents and induction of mechanical allodynia. In addition, accumulating information suggests the involvement of G protein-coupled ATP receptors in the modulation of the generation and transmission of pain. SN - 0015-5691 UR - https://www.unboundmedicine.com/medline/citation/11188502/[ATP_receptors_in_pain]_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0015-5691&volume=116&issue=6&spage=343 DB - PRIME DP - Unbound Medicine ER -