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Complications and limitations of drug therapy for Parkinson's disease.
Neurology. 2000; 55(12 Suppl 6):S2-6.Neur

Abstract

Levodopa is the most effective drug treatment for Parkinson's disease (PD). However, its chronic use is associated with dyskinesia, motor fluctuations, and hallucinations. There are various approaches to the management of levodopa complications. Motor fluctuations can be treated with a long-acting levodopa preparation, liquid levodopa, or the addition of dopamine agonists or catechol-O-methyl transferase (COMT) inhibitors. Drugs that may improve levodopa-induced psychiatric complications are olanzapine, clozapine, and ondansetron. A large proportion of patients with long-standing PD cannot be controlled adequately with the available pharmacologic tools and are candidates for surgery. Pallidotomy and deep brain stimulation (DBS) of the globus pallidum pars interna and the subthalamic nucleus are currently the preferred surgical approaches. Appropriate patient selection becomes a critical issue for achieving the best surgical results.

Authors+Show Affiliations

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11188970

Citation

Jankovic, J. "Complications and Limitations of Drug Therapy for Parkinson's Disease." Neurology, vol. 55, no. 12 Suppl 6, 2000, pp. S2-6.
Jankovic J. Complications and limitations of drug therapy for Parkinson's disease. Neurology. 2000;55(12 Suppl 6):S2-6.
Jankovic, J. (2000). Complications and limitations of drug therapy for Parkinson's disease. Neurology, 55(12 Suppl 6), S2-6.
Jankovic J. Complications and Limitations of Drug Therapy for Parkinson's Disease. Neurology. 2000;55(12 Suppl 6):S2-6. PubMed PMID: 11188970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complications and limitations of drug therapy for Parkinson's disease. A1 - Jankovic,J, PY - 2001/2/24/pubmed PY - 2001/2/28/medline PY - 2001/2/24/entrez SP - S2 EP - 6 JF - Neurology JO - Neurology VL - 55 IS - 12 Suppl 6 N2 - Levodopa is the most effective drug treatment for Parkinson's disease (PD). However, its chronic use is associated with dyskinesia, motor fluctuations, and hallucinations. There are various approaches to the management of levodopa complications. Motor fluctuations can be treated with a long-acting levodopa preparation, liquid levodopa, or the addition of dopamine agonists or catechol-O-methyl transferase (COMT) inhibitors. Drugs that may improve levodopa-induced psychiatric complications are olanzapine, clozapine, and ondansetron. A large proportion of patients with long-standing PD cannot be controlled adequately with the available pharmacologic tools and are candidates for surgery. Pallidotomy and deep brain stimulation (DBS) of the globus pallidum pars interna and the subthalamic nucleus are currently the preferred surgical approaches. Appropriate patient selection becomes a critical issue for achieving the best surgical results. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/11188970/Complications_and_limitations_of_drug_therapy_for_Parkinson's_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11188970.ui DB - PRIME DP - Unbound Medicine ER -
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