Tags

Type your tag names separated by a space and hit enter

[Genetic diagnosis of alpha and beta thalassemia dual heterozygote].
Zhonghua Xue Ye Xue Za Zhi. 1998 Oct; 19(10):525-7.ZX

Abstract

OBJECTIVE

To perform genetic diagnosis of alpha and beta thalassemia dual heterozygotes.

METHODS

PCR and beta-thalassemia allele specific oligonucleotide probe/reverse dot blot(ASO/RDB) techniques were used.

RESULTS

Six cases of suspected alpha-thalassemia-1 and beta-thalassemia dual heterozygotes were found in genetic counseling and prenatal diagnosis. On genetic diagnosis, they were all Southeast Asia(SEA) type of alpha-thalassemia-1 and beta-thalassemia (--SEA/alpha alpha, beta T/beta A) dual heterozygotes. Out of them, 3 cases were alpha-thalassemia-1 and beta 41-42 (-TCTT), 2 were alpha-thalassemia-1 and beta-28(A-->T) and 1 was alpha-thalassemia-1 and beta IVS-II-654(C-->T) double heterozygotes.

CONCLUSION

The detection of thalassemia dual heterozygotes facilitates the prenatal diagnosis with more precision.

Authors+Show Affiliations

Medical Genetics Department, Sun Yatsen University of Medical Sciences, Guangzhou 510089.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11189497

Citation

Zeng, R, et al. "[Genetic Diagnosis of Alpha and Beta Thalassemia Dual Heterozygote]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 19, no. 10, 1998, pp. 525-7.
Zeng R, Yu S, Hu B. [Genetic diagnosis of alpha and beta thalassemia dual heterozygote]. Zhonghua Xue Ye Xue Za Zhi. 1998;19(10):525-7.
Zeng, R., Yu, S., & Hu, B. (1998). [Genetic diagnosis of alpha and beta thalassemia dual heterozygote]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 19(10), 525-7.
Zeng R, Yu S, Hu B. [Genetic Diagnosis of Alpha and Beta Thalassemia Dual Heterozygote]. Zhonghua Xue Ye Xue Za Zhi. 1998;19(10):525-7. PubMed PMID: 11189497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic diagnosis of alpha and beta thalassemia dual heterozygote]. AU - Zeng,R, AU - Yu,S, AU - Hu,B, PY - 2001/2/24/pubmed PY - 2001/2/28/medline PY - 2001/2/24/entrez SP - 525 EP - 7 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 19 IS - 10 N2 - OBJECTIVE: To perform genetic diagnosis of alpha and beta thalassemia dual heterozygotes. METHODS: PCR and beta-thalassemia allele specific oligonucleotide probe/reverse dot blot(ASO/RDB) techniques were used. RESULTS: Six cases of suspected alpha-thalassemia-1 and beta-thalassemia dual heterozygotes were found in genetic counseling and prenatal diagnosis. On genetic diagnosis, they were all Southeast Asia(SEA) type of alpha-thalassemia-1 and beta-thalassemia (--SEA/alpha alpha, beta T/beta A) dual heterozygotes. Out of them, 3 cases were alpha-thalassemia-1 and beta 41-42 (-TCTT), 2 were alpha-thalassemia-1 and beta-28(A-->T) and 1 was alpha-thalassemia-1 and beta IVS-II-654(C-->T) double heterozygotes. CONCLUSION: The detection of thalassemia dual heterozygotes facilitates the prenatal diagnosis with more precision. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/11189497/[Genetic_diagnosis_of_alpha_and_beta_thalassemia_dual_heterozygote]_ L2 - http://www.diseaseinfosearch.org/result/814 DB - PRIME DP - Unbound Medicine ER -