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Microbial models of mammalian metabolism: microbial transformation of naproxen.
Pharmazie. 2000 Dec; 55(12):934-6.P

Abstract

Preparative-scale fermentation of S-naproxen, the known antiinflammatory, analgesic and antipyretic drug, with Cunninghamella elegans ATCC 9245 afforded S-demethylnaproxen, the known human active metabolite of naproxen, in a 90% yield. Demethylnaproxen was also detected as the major metabolite of naproxen using Cunninghamella blakesleeana ATCC 8688a. A review of the previous microbial metabolism studies using the fungi Cunninghamella species suggested that it could be a plausible in vitro predictor for mammalian metabolism.

Authors+Show Affiliations

Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Saudi Arabia. elsayed99@yahoo.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11189871

Citation

el Sayed, K A.. "Microbial Models of Mammalian Metabolism: Microbial Transformation of Naproxen." Die Pharmazie, vol. 55, no. 12, 2000, pp. 934-6.
el Sayed KA. Microbial models of mammalian metabolism: microbial transformation of naproxen. Pharmazie. 2000;55(12):934-6.
el Sayed, K. A. (2000). Microbial models of mammalian metabolism: microbial transformation of naproxen. Die Pharmazie, 55(12), 934-6.
el Sayed KA. Microbial Models of Mammalian Metabolism: Microbial Transformation of Naproxen. Pharmazie. 2000;55(12):934-6. PubMed PMID: 11189871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial models of mammalian metabolism: microbial transformation of naproxen. A1 - el Sayed,K A, PY - 2001/2/24/pubmed PY - 2001/3/3/medline PY - 2001/2/24/entrez SP - 934 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 55 IS - 12 N2 - Preparative-scale fermentation of S-naproxen, the known antiinflammatory, analgesic and antipyretic drug, with Cunninghamella elegans ATCC 9245 afforded S-demethylnaproxen, the known human active metabolite of naproxen, in a 90% yield. Demethylnaproxen was also detected as the major metabolite of naproxen using Cunninghamella blakesleeana ATCC 8688a. A review of the previous microbial metabolism studies using the fungi Cunninghamella species suggested that it could be a plausible in vitro predictor for mammalian metabolism. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/11189871/Microbial_models_of_mammalian_metabolism:_microbial_transformation_of_naproxen_ DB - PRIME DP - Unbound Medicine ER -