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The role of erythrocyte protoporphyrin in the diagnosis of iron deficiency anemia of children.
J Trop Pediatr. 2000 12; 46(6):323-6.JT

Abstract

The values of erythrocyte protoporphyrin, ferritin and mean corpuscular volume (MCV) measurements in diagnosing iron deficiency anemia were investigated in 72 iron deficient and in 25 healthy control infants. Receiver operator curve, sensitivity and specificity of erythrocyte protoporphyrin, ferritin and mean corpuscular volume were compared between the study and control groups. In the study group mean corpuscular volume, hemoglobin and ferritin concentrations were significantly lower, and erythrocyte protoporphyrin was significantly higher when compared to the control group. In the iron deficient study group, erythrocyte protoporphyrin was the most sensitive test and ferritin was the most specific test, whereas ferritin was the most diagnostic test and mean corpuscular volume was the least diagnostic test. A significant correlation between erythrocyte protoporphyrin and hemoglobin values was determined. We conclude that erythrocyte protoporphyrin is a more sensitive but less specific test than ferritin, and it can be used as a first-line diagnostic test in the evaluation of iron deficiency and in diagnosing iron deficiency anemia in infants.

Authors+Show Affiliations

Department of Biochemistry of Gülhane Military Medical Academy, Ankara, Turkey. maserdar@hotmail.com>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

11191140

Citation

Serdar, M A., et al. "The Role of Erythrocyte Protoporphyrin in the Diagnosis of Iron Deficiency Anemia of Children." Journal of Tropical Pediatrics, vol. 46, no. 6, 2000, pp. 323-6.
Serdar MA, Sarici SU, Kurt I, et al. The role of erythrocyte protoporphyrin in the diagnosis of iron deficiency anemia of children. J Trop Pediatr. 2000;46(6):323-6.
Serdar, M. A., Sarici, S. U., Kurt, I., Alpay, F., Okutan, V., Kurnaz, L., & Kutluay, T. (2000). The role of erythrocyte protoporphyrin in the diagnosis of iron deficiency anemia of children. Journal of Tropical Pediatrics, 46(6), 323-6. https://doi.org/10.1093/tropej/46.6.323
Serdar MA, et al. The Role of Erythrocyte Protoporphyrin in the Diagnosis of Iron Deficiency Anemia of Children. J Trop Pediatr. 2000;46(6):323-6. PubMed PMID: 11191140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of erythrocyte protoporphyrin in the diagnosis of iron deficiency anemia of children. AU - Serdar,M A, AU - Sarici,S U, AU - Kurt,I, AU - Alpay,F, AU - Okutan,V, AU - Kurnaz,L, AU - Kutluay,T, PY - 2001/2/24/pubmed PY - 2001/3/27/medline PY - 2001/2/24/entrez SP - 323 EP - 6 JF - Journal of tropical pediatrics JO - J Trop Pediatr VL - 46 IS - 6 N2 - The values of erythrocyte protoporphyrin, ferritin and mean corpuscular volume (MCV) measurements in diagnosing iron deficiency anemia were investigated in 72 iron deficient and in 25 healthy control infants. Receiver operator curve, sensitivity and specificity of erythrocyte protoporphyrin, ferritin and mean corpuscular volume were compared between the study and control groups. In the study group mean corpuscular volume, hemoglobin and ferritin concentrations were significantly lower, and erythrocyte protoporphyrin was significantly higher when compared to the control group. In the iron deficient study group, erythrocyte protoporphyrin was the most sensitive test and ferritin was the most specific test, whereas ferritin was the most diagnostic test and mean corpuscular volume was the least diagnostic test. A significant correlation between erythrocyte protoporphyrin and hemoglobin values was determined. We conclude that erythrocyte protoporphyrin is a more sensitive but less specific test than ferritin, and it can be used as a first-line diagnostic test in the evaluation of iron deficiency and in diagnosing iron deficiency anemia in infants. SN - 0142-6338 UR - https://www.unboundmedicine.com/medline/citation/11191140/The_role_of_erythrocyte_protoporphyrin_in_the_diagnosis_of_iron_deficiency_anemia_of_children_ L2 - https://academic.oup.com/tropej/article-lookup/doi/10.1093/tropej/46.6.323 DB - PRIME DP - Unbound Medicine ER -