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The association of low serum cholesterol with depression and suicidal behaviours: new hypotheses for the missing link.
J Int Med Res. 2000 Nov-Dec; 28(6):247-57.JI

Abstract

Several observational studies indicate that reduction of serum cholesterol levels is related to an increase in violent deaths and suicide but the nature of this possible relationship remains unclear. Many confounding factors, e.g. poor health, depression and loss of appetite may play a role in the apparent relationship between serum cholesterol levels and suicide. Two separate phenomena should be considered: lowering total cholesterol and low total cholesterol. This review considers the evidence from epidemiological studies on serum cholesterol lowering and psychiatric disturbances. The available evidence does not seem to substantiate the view that large-scale intervention to reduce cholesterol concentrations could lead to more violent and aggressive behaviour, and generally greater unhappiness. In recent trials using statin treatment, there were slightly fewer deaths from accidents and suicide in the treated group compared with the placebo group. We believe that clinicians should not be deterred from prescribing cholesterol-lowering drugs, to reduce the risk of death from coronary heart disease, when they are indicated.

Authors+Show Affiliations

Manfredini R
Department of Clinical and Experimental Medicine, University of Ferrara, Italy. mfr@unife.it
Caracciolo S
No affiliation info available
Salmi R
No affiliation info available
Boari B
No affiliation info available
Tomelli A
No affiliation info available
Gallerani M
No affiliation info available

MeSH

AggressionAnticholesteremic AgentsCardiovascular DiseasesCholesterolDepressionHumansHypercholesterolemiaModels, PsychologicalSuicideViolence

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11191718

Citation

Manfredini, R, et al. "The Association of Low Serum Cholesterol With Depression and Suicidal Behaviours: New Hypotheses for the Missing Link." The Journal of International Medical Research, vol. 28, no. 6, 2000, pp. 247-57.
Manfredini R, Caracciolo S, Salmi R, et al. The association of low serum cholesterol with depression and suicidal behaviours: new hypotheses for the missing link. J Int Med Res. 2000;28(6):247-57.
Manfredini, R., Caracciolo, S., Salmi, R., Boari, B., Tomelli, A., & Gallerani, M. (2000). The association of low serum cholesterol with depression and suicidal behaviours: new hypotheses for the missing link. The Journal of International Medical Research, 28(6), 247-57.
Manfredini R, et al. The Association of Low Serum Cholesterol With Depression and Suicidal Behaviours: New Hypotheses for the Missing Link. J Int Med Res. 2000 Nov-Dec;28(6):247-57. PubMed PMID: 11191718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of low serum cholesterol with depression and suicidal behaviours: new hypotheses for the missing link. AU - Manfredini,R, AU - Caracciolo,S, AU - Salmi,R, AU - Boari,B, AU - Tomelli,A, AU - Gallerani,M, PY - 2001/2/24/pubmed PY - 2001/3/17/medline PY - 2001/2/24/entrez SP - 247 EP - 57 JF - The Journal of international medical research JO - J Int Med Res VL - 28 IS - 6 N2 - Several observational studies indicate that reduction of serum cholesterol levels is related to an increase in violent deaths and suicide but the nature of this possible relationship remains unclear. Many confounding factors, e.g. poor health, depression and loss of appetite may play a role in the apparent relationship between serum cholesterol levels and suicide. Two separate phenomena should be considered: lowering total cholesterol and low total cholesterol. This review considers the evidence from epidemiological studies on serum cholesterol lowering and psychiatric disturbances. The available evidence does not seem to substantiate the view that large-scale intervention to reduce cholesterol concentrations could lead to more violent and aggressive behaviour, and generally greater unhappiness. In recent trials using statin treatment, there were slightly fewer deaths from accidents and suicide in the treated group compared with the placebo group. We believe that clinicians should not be deterred from prescribing cholesterol-lowering drugs, to reduce the risk of death from coronary heart disease, when they are indicated. SN - 0300-0605 UR - https://www.unboundmedicine.com/medline/citation/11191718/The_association_of_low_serum_cholesterol_with_depression_and_suicidal_behaviours:_new_hypotheses_for_the_missing_link_ DB - PRIME DP - Unbound Medicine ER -