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Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q.
Genes Immun. 2000 Oct; 1(7):456-9.GI

Abstract

To date, four genome screens have been completed in the demyelinating autoimmune disease multiple sclerosis (MS). Although these screens failed to identify any loci with major effects on susceptibility, several novel regions of potential linkage were suggested, including the long arm of chromosome 17. In order to further pursue this promising region we have investigated six highly polymorphic microsatellite markers in 115 Scandinavian families with MS affected sib pairs. Multipoint linkage analysis revealed a peak maximum likelihood score (MLS) of 0.9 in the region of marker D17S787. Stratifying the results on the basis of HLA-DR2 status showed that the linkage was not limited to families segregating for the HLA-DR2 allele as has previously been suggested. In conclusion, our results further support the proposal that a multiple sclerosis susceptibility locus is contained on chromosome 17q.

Authors+Show Affiliations

Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. flar@biobase.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11196677

Citation

Larsen, F, et al. "Linkage Analysis of a Candidate Region in Scandinavian Sib Pairs With Multiple Sclerosis Reveals Linkage to Chromosome 17q." Genes and Immunity, vol. 1, no. 7, 2000, pp. 456-9.
Larsen F, Oturai A, Ryder LP, et al. Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q. Genes Immun. 2000;1(7):456-9.
Larsen, F., Oturai, A., Ryder, L. P., Madsen, H. O., Hillert, J., Fredrikson, S., Sandberg-Wollheim, M., Laaksonen, M., Harbo, H. F., Sawcer, S., Fugger, L., Sorensen, P. S., & Svejgaard, A. (2000). Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q. Genes and Immunity, 1(7), 456-9.
Larsen F, et al. Linkage Analysis of a Candidate Region in Scandinavian Sib Pairs With Multiple Sclerosis Reveals Linkage to Chromosome 17q. Genes Immun. 2000;1(7):456-9. PubMed PMID: 11196677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q. AU - Larsen,F, AU - Oturai,A, AU - Ryder,L P, AU - Madsen,H O, AU - Hillert,J, AU - Fredrikson,S, AU - Sandberg-Wollheim,M, AU - Laaksonen,M, AU - Harbo,H F, AU - Sawcer,S, AU - Fugger,L, AU - Sorensen,P S, AU - Svejgaard,A, PY - 2001/2/24/pubmed PY - 2001/3/10/medline PY - 2001/2/24/entrez SP - 456 EP - 9 JF - Genes and immunity JO - Genes Immun. VL - 1 IS - 7 N2 - To date, four genome screens have been completed in the demyelinating autoimmune disease multiple sclerosis (MS). Although these screens failed to identify any loci with major effects on susceptibility, several novel regions of potential linkage were suggested, including the long arm of chromosome 17. In order to further pursue this promising region we have investigated six highly polymorphic microsatellite markers in 115 Scandinavian families with MS affected sib pairs. Multipoint linkage analysis revealed a peak maximum likelihood score (MLS) of 0.9 in the region of marker D17S787. Stratifying the results on the basis of HLA-DR2 status showed that the linkage was not limited to families segregating for the HLA-DR2 allele as has previously been suggested. In conclusion, our results further support the proposal that a multiple sclerosis susceptibility locus is contained on chromosome 17q. SN - 1466-4879 UR - https://www.unboundmedicine.com/medline/citation/11196677/Linkage_analysis_of_a_candidate_region_in_Scandinavian_sib_pairs_with_multiple_sclerosis_reveals_linkage_to_chromosome_17q_ L2 - http://dx.doi.org/10.1038/sj.gene.6363705 DB - PRIME DP - Unbound Medicine ER -