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Separation of cold medicine ingredients by capillary electrophoresis.
Electrophoresis. 2001 Jan; 22(1):139-43.E

Abstract

This study demonstrates the separation of cold medicine ingredients (e.g., phenylpropanolamine, dextromethorphan, chlorpheniramine maleate, and paracetamol) by capillary zone electrophoresis and micellar electrokinetic chromatography. Factors affecting their separations were the buffer pH and the concentrations of buffer, surfactant and organic modifiers. Optimum results were obtained with a 10 mM sodium dihydrogen-phosphate-sodium tetraborate buffer containing 50 mM sodium dodecyl sulfate (SDS) and 5% methanol (MeOH), pH 9.0. The carrier electrolyte gave a baseline separation of phenylpropanolamine, dextromethorphan, chlorpheniramine maleate, and paracetamol with a resolution of 1.2, and the total migration time was 11.38 min.

Authors+Show Affiliations

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhaya Rd., Rajathevee, Bangkok 10400, Thailand. lleena65@hotmail.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11197163

Citation

Suntornsuk, L. "Separation of Cold Medicine Ingredients By Capillary Electrophoresis." Electrophoresis, vol. 22, no. 1, 2001, pp. 139-43.
Suntornsuk L. Separation of cold medicine ingredients by capillary electrophoresis. Electrophoresis. 2001;22(1):139-43.
Suntornsuk, L. (2001). Separation of cold medicine ingredients by capillary electrophoresis. Electrophoresis, 22(1), 139-43.
Suntornsuk L. Separation of Cold Medicine Ingredients By Capillary Electrophoresis. Electrophoresis. 2001;22(1):139-43. PubMed PMID: 11197163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Separation of cold medicine ingredients by capillary electrophoresis. A1 - Suntornsuk,L, PY - 2001/2/24/pubmed PY - 2001/5/1/medline PY - 2001/2/24/entrez SP - 139 EP - 43 JF - Electrophoresis JO - Electrophoresis VL - 22 IS - 1 N2 - This study demonstrates the separation of cold medicine ingredients (e.g., phenylpropanolamine, dextromethorphan, chlorpheniramine maleate, and paracetamol) by capillary zone electrophoresis and micellar electrokinetic chromatography. Factors affecting their separations were the buffer pH and the concentrations of buffer, surfactant and organic modifiers. Optimum results were obtained with a 10 mM sodium dihydrogen-phosphate-sodium tetraborate buffer containing 50 mM sodium dodecyl sulfate (SDS) and 5% methanol (MeOH), pH 9.0. The carrier electrolyte gave a baseline separation of phenylpropanolamine, dextromethorphan, chlorpheniramine maleate, and paracetamol with a resolution of 1.2, and the total migration time was 11.38 min. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/11197163/Separation_of_cold_medicine_ingredients_by_capillary_electrophoresis_ L2 - https://doi.org/10.1002/1522-2683(200101)22:1<139::AID-ELPS139>3.0.CO;2-D DB - PRIME DP - Unbound Medicine ER -