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Risk factors for erosive reflux esophagitis: a case-control study.
Am J Gastroenterol. 2001 Jan; 96(1):41-6.AJ

Abstract

OBJECTIVES

It is presently not fully understood which risk factors contribute to the occurrence of reflux esophagitis and how such factors might influence the severity of the disease. The aim of this study was to delineate the clinical epidemiology of erosive reflux esophagitis.

METHODS

Outpatients from a medicine and gastroenterology clinic who underwent upper GI endoscopy were recruited into a case-control study. A total of 1,533 patients with and 3,428 patients without endoscopically diagnosed reflux esophagitis were categorized as case and control subjects, respectively. Using multivariate logistic regressions for statistical analysis, the presence of esophageal erosions, ulcers or strictures, served as three separate outcome variables. Demographic characteristics, intake of nonsteroidal anti-inflammatory drugs (NSAIDs), consumption of alcohol and cigarettes, and the presence of hiatus hernia or peptic ulcer served as predictor variables.

RESULTS

Erosive reflux esophagitis tended to occur more frequently in Caucasian male patients. Hiatus hernia was associated with a strong risk for developing esophageal erosions, ulcers, and strictures. Although statistical significance was demonstrated only for esophageal erosions, in all grades of reflux esophagitis alike, gastric and duodenal ulcer exerted a protective influence. Consumption of NSAIDs increased the risk for esophageal ulcers only. Smoking and alcohol were not associated with an increased risk of developing any type of erosive reflux esophagitis.

CONCLUSIONS

The results stress the critical role played by hiatus hernia in all grades of erosive reflux esophagitis. NSAIDs may act through a mechanism of topically induced esophageal injury. Our data also suggest that the presence of either gastric or duodenal ulcer exerts a protective influence against the development of reflux disease.

Authors+Show Affiliations

Department of Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11197285

Citation

Avidan, B, et al. "Risk Factors for Erosive Reflux Esophagitis: a Case-control Study." The American Journal of Gastroenterology, vol. 96, no. 1, 2001, pp. 41-6.
Avidan B, Sonnenberg A, Schnell TG, et al. Risk factors for erosive reflux esophagitis: a case-control study. Am J Gastroenterol. 2001;96(1):41-6.
Avidan, B., Sonnenberg, A., Schnell, T. G., & Sontag, S. J. (2001). Risk factors for erosive reflux esophagitis: a case-control study. The American Journal of Gastroenterology, 96(1), 41-6.
Avidan B, et al. Risk Factors for Erosive Reflux Esophagitis: a Case-control Study. Am J Gastroenterol. 2001;96(1):41-6. PubMed PMID: 11197285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for erosive reflux esophagitis: a case-control study. AU - Avidan,B, AU - Sonnenberg,A, AU - Schnell,T G, AU - Sontag,S J, PY - 2001/2/24/pubmed PY - 2001/3/3/medline PY - 2001/2/24/entrez SP - 41 EP - 6 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 96 IS - 1 N2 - OBJECTIVES: It is presently not fully understood which risk factors contribute to the occurrence of reflux esophagitis and how such factors might influence the severity of the disease. The aim of this study was to delineate the clinical epidemiology of erosive reflux esophagitis. METHODS: Outpatients from a medicine and gastroenterology clinic who underwent upper GI endoscopy were recruited into a case-control study. A total of 1,533 patients with and 3,428 patients without endoscopically diagnosed reflux esophagitis were categorized as case and control subjects, respectively. Using multivariate logistic regressions for statistical analysis, the presence of esophageal erosions, ulcers or strictures, served as three separate outcome variables. Demographic characteristics, intake of nonsteroidal anti-inflammatory drugs (NSAIDs), consumption of alcohol and cigarettes, and the presence of hiatus hernia or peptic ulcer served as predictor variables. RESULTS: Erosive reflux esophagitis tended to occur more frequently in Caucasian male patients. Hiatus hernia was associated with a strong risk for developing esophageal erosions, ulcers, and strictures. Although statistical significance was demonstrated only for esophageal erosions, in all grades of reflux esophagitis alike, gastric and duodenal ulcer exerted a protective influence. Consumption of NSAIDs increased the risk for esophageal ulcers only. Smoking and alcohol were not associated with an increased risk of developing any type of erosive reflux esophagitis. CONCLUSIONS: The results stress the critical role played by hiatus hernia in all grades of erosive reflux esophagitis. NSAIDs may act through a mechanism of topically induced esophageal injury. Our data also suggest that the presence of either gastric or duodenal ulcer exerts a protective influence against the development of reflux disease. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11197285/Risk_factors_for_erosive_reflux_esophagitis:_a_case_control_study_ L2 - http://Insights.ovid.com/pubmed?pmid=11197285 DB - PRIME DP - Unbound Medicine ER -