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Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life.
Am J Gastroenterol. 2001 Jan; 96(1):71-6.AJ

Abstract

OBJECTIVES

Morbidity from GI symptoms in diabetes is considered to be high, but no studies have quantified the impact of GI symptoms in diabetes on health-related quality of life. We hypothesized that diabetics reporting increased GI symptoms would experience more impaired quality of life.

METHODS

Subjects from the community with diabetes (n = 892) and outpatients with diabetes (n = 209) were recruited for this study. Subjects were divided into type 1 (diabetes diagnosed at age <30 yr and requiring insulin) and type 2. A validated questionnaire measuring GI symptoms and diabetes status and the Short Form-36 were completed. The results were compared with Australian normal data. GI symptom groups measured were frequent abdominal pain, bowel-related abdominal pain, reflux, dyspepsia, constipation, diarrhea, and fecal incontinence.

RESULTS

There was a clinically significant decrease in quality-of-life scores in diabetics compared with population norms across all subscales. The impact on quality of life in diabetes was predominantly observed in type 2 diabetics. The quality-of-life scores in all subscales decreased markedly with increasing numbers of distinct GI symptom groups, and this was similar in community and outpatient diabetics. For all the Short Form-36 subscales, GI symptom groups were significantly (all p < 0.0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes.

CONCLUSIONS

GI symptoms impact negatively on health-related quality of life in diabetes mellitus.

Authors+Show Affiliations

Department of Medicine, University of Sydney, Nepean Hospital, Kingswood, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11197290

Citation

Talley, N J., et al. "Impact of Chronic Gastrointestinal Symptoms in Diabetes Mellitus On Health-related Quality of Life." The American Journal of Gastroenterology, vol. 96, no. 1, 2001, pp. 71-6.
Talley NJ, Young L, Bytzer P, et al. Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life. Am J Gastroenterol. 2001;96(1):71-6.
Talley, N. J., Young, L., Bytzer, P., Hammer, J., Leemon, M., Jones, M., & Horowitz, M. (2001). Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life. The American Journal of Gastroenterology, 96(1), 71-6.
Talley NJ, et al. Impact of Chronic Gastrointestinal Symptoms in Diabetes Mellitus On Health-related Quality of Life. Am J Gastroenterol. 2001;96(1):71-6. PubMed PMID: 11197290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life. AU - Talley,N J, AU - Young,L, AU - Bytzer,P, AU - Hammer,J, AU - Leemon,M, AU - Jones,M, AU - Horowitz,M, PY - 2001/2/24/pubmed PY - 2001/3/3/medline PY - 2001/2/24/entrez SP - 71 EP - 6 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 96 IS - 1 N2 - OBJECTIVES: Morbidity from GI symptoms in diabetes is considered to be high, but no studies have quantified the impact of GI symptoms in diabetes on health-related quality of life. We hypothesized that diabetics reporting increased GI symptoms would experience more impaired quality of life. METHODS: Subjects from the community with diabetes (n = 892) and outpatients with diabetes (n = 209) were recruited for this study. Subjects were divided into type 1 (diabetes diagnosed at age <30 yr and requiring insulin) and type 2. A validated questionnaire measuring GI symptoms and diabetes status and the Short Form-36 were completed. The results were compared with Australian normal data. GI symptom groups measured were frequent abdominal pain, bowel-related abdominal pain, reflux, dyspepsia, constipation, diarrhea, and fecal incontinence. RESULTS: There was a clinically significant decrease in quality-of-life scores in diabetics compared with population norms across all subscales. The impact on quality of life in diabetes was predominantly observed in type 2 diabetics. The quality-of-life scores in all subscales decreased markedly with increasing numbers of distinct GI symptom groups, and this was similar in community and outpatient diabetics. For all the Short Form-36 subscales, GI symptom groups were significantly (all p < 0.0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes. CONCLUSIONS: GI symptoms impact negatively on health-related quality of life in diabetes mellitus. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11197290/Impact_of_chronic_gastrointestinal_symptoms_in_diabetes_mellitus_on_health_related_quality_of_life_ L2 - https://doi.org/10.1111/j.1572-0241.2001.03350.x DB - PRIME DP - Unbound Medicine ER -