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Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache?
Ann Neurol 2001; 49(1):7-13AN

Abstract

The time course of propagation of scotoma and blood flow changes during migraine aura parallels the phenomenon of cortical spreading depression (CSD). It was proposed that CSD generates a sterile neurogenic inflammation in the meninges, which may then lead to the activation or sensitization of nociceptors, thus generating headache. We performed rat experiments in which the effect of CSD on plasma extravasation in the dura mater and on neuronal activity in deep laminae of the trigeminal nucleus was assessed in vivo. CSD did not alter dural plasma extravasation measured by means of bovine serum albumin-coupled flourescein (n = 17 rats) compared to the CSD-free contralateral side. In an in vitro model, the application of KCl to the dura at concentrations extracellularly found during CSD did not alter the release of calcitonin gene-related peptide and prostaglandin E2 from the dura. In 33 rats, neither single CSDs nor a series of CSDs altered ongoing neuronal activity or mechanical and/or thermal sensitivity of the deeply located neurons to stimulation of their receptive fields in the dura mater. These results are at variance with data that showed increased c-Fos labeling in superficial laminae of the trigeminal nucleus following CSD. They do not suggest that CSD initiates migraine headache via neurogenic inflammation.

Authors+Show Affiliations

Department of Physiology, University of Jena, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11198299

Citation

Ebersberger, A, et al. "Is There a Correlation Between Spreading Depression, Neurogenic Inflammation, and Nociception That Might Cause Migraine Headache?" Annals of Neurology, vol. 49, no. 1, 2001, pp. 7-13.
Ebersberger A, Schaible HG, Averbeck B, et al. Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache? Ann Neurol. 2001;49(1):7-13.
Ebersberger, A., Schaible, H. G., Averbeck, B., & Richter, F. (2001). Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache? Annals of Neurology, 49(1), pp. 7-13.
Ebersberger A, et al. Is There a Correlation Between Spreading Depression, Neurogenic Inflammation, and Nociception That Might Cause Migraine Headache. Ann Neurol. 2001;49(1):7-13. PubMed PMID: 11198299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache? AU - Ebersberger,A, AU - Schaible,H G, AU - Averbeck,B, AU - Richter,F, PY - 2001/2/24/pubmed PY - 2001/3/3/medline PY - 2001/2/24/entrez SP - 7 EP - 13 JF - Annals of neurology JO - Ann. Neurol. VL - 49 IS - 1 N2 - The time course of propagation of scotoma and blood flow changes during migraine aura parallels the phenomenon of cortical spreading depression (CSD). It was proposed that CSD generates a sterile neurogenic inflammation in the meninges, which may then lead to the activation or sensitization of nociceptors, thus generating headache. We performed rat experiments in which the effect of CSD on plasma extravasation in the dura mater and on neuronal activity in deep laminae of the trigeminal nucleus was assessed in vivo. CSD did not alter dural plasma extravasation measured by means of bovine serum albumin-coupled flourescein (n = 17 rats) compared to the CSD-free contralateral side. In an in vitro model, the application of KCl to the dura at concentrations extracellularly found during CSD did not alter the release of calcitonin gene-related peptide and prostaglandin E2 from the dura. In 33 rats, neither single CSDs nor a series of CSDs altered ongoing neuronal activity or mechanical and/or thermal sensitivity of the deeply located neurons to stimulation of their receptive fields in the dura mater. These results are at variance with data that showed increased c-Fos labeling in superficial laminae of the trigeminal nucleus following CSD. They do not suggest that CSD initiates migraine headache via neurogenic inflammation. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/11198299/Is_there_a_correlation_between_spreading_depression_neurogenic_inflammation_and_nociception_that_might_cause_migraine_headache L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2001&volume=49&issue=1&spage=7 DB - PRIME DP - Unbound Medicine ER -