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Lack of activation of human secondary somatosensory cortex in Unverricht-Lundborg type of progressive myoclonus epilepsy.
Ann Neurol. 2001 Jan; 49(1):90-7.AN

Abstract

Previous electroencephalographic and magnetoencephalographic studies have demonstrated giant early somatosensory cortical responses in patients with cortical myoclonus. We applied whole-scalp magnetoencephalography to study activation sequences of the somatosensory cortical network in 7 patients with Unverricht-Lundborg-type progressive myoclonus epilepsy diagnostically verified by DNA analysis. Responses to electric median nerve stimuli displayed 30-msec peaks at the contralateral primary somatosensory cortex that were four times stronger in patients than in control subjects. The amplitudes of 20-msec responses did not significantly differ between the groups. In contrast to control subjects, 5 patients displayed ipsilateral primary somatosensory cortex activity at 48 to 61 msec in response to both left- and right-sided median nerve stimuli. Furthermore, their secondary somatosensory cortex was not significantly activated. These abnormalities indicate altered responsiveness of the entire somatosensory cortical network outside the contralateral primary somatosensory cortex in patients with Unverricht-Lundborg-type progressive myoclonus epilepsy. The deficient activation of the secondary somatosensory cortex in Unverricht-Lundborg patients may reflect disturbed sensorimotor integration, probably related to impaired movement coordination.

Authors+Show Affiliations

Brain Research Unit, Helsinki University of Technology, Espoo, Finland. nina@neuro.hut.fiNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11198301

Citation

Forss, N, et al. "Lack of Activation of Human Secondary Somatosensory Cortex in Unverricht-Lundborg Type of Progressive Myoclonus Epilepsy." Annals of Neurology, vol. 49, no. 1, 2001, pp. 90-7.
Forss N, Silén T, Karjalainen T. Lack of activation of human secondary somatosensory cortex in Unverricht-Lundborg type of progressive myoclonus epilepsy. Ann Neurol. 2001;49(1):90-7.
Forss, N., Silén, T., & Karjalainen, T. (2001). Lack of activation of human secondary somatosensory cortex in Unverricht-Lundborg type of progressive myoclonus epilepsy. Annals of Neurology, 49(1), 90-7.
Forss N, Silén T, Karjalainen T. Lack of Activation of Human Secondary Somatosensory Cortex in Unverricht-Lundborg Type of Progressive Myoclonus Epilepsy. Ann Neurol. 2001;49(1):90-7. PubMed PMID: 11198301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of activation of human secondary somatosensory cortex in Unverricht-Lundborg type of progressive myoclonus epilepsy. AU - Forss,N, AU - Silén,T, AU - Karjalainen,T, PY - 2001/2/24/pubmed PY - 2001/3/3/medline PY - 2001/2/24/entrez SP - 90 EP - 7 JF - Annals of neurology JO - Ann Neurol VL - 49 IS - 1 N2 - Previous electroencephalographic and magnetoencephalographic studies have demonstrated giant early somatosensory cortical responses in patients with cortical myoclonus. We applied whole-scalp magnetoencephalography to study activation sequences of the somatosensory cortical network in 7 patients with Unverricht-Lundborg-type progressive myoclonus epilepsy diagnostically verified by DNA analysis. Responses to electric median nerve stimuli displayed 30-msec peaks at the contralateral primary somatosensory cortex that were four times stronger in patients than in control subjects. The amplitudes of 20-msec responses did not significantly differ between the groups. In contrast to control subjects, 5 patients displayed ipsilateral primary somatosensory cortex activity at 48 to 61 msec in response to both left- and right-sided median nerve stimuli. Furthermore, their secondary somatosensory cortex was not significantly activated. These abnormalities indicate altered responsiveness of the entire somatosensory cortical network outside the contralateral primary somatosensory cortex in patients with Unverricht-Lundborg-type progressive myoclonus epilepsy. The deficient activation of the secondary somatosensory cortex in Unverricht-Lundborg patients may reflect disturbed sensorimotor integration, probably related to impaired movement coordination. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/11198301/Lack_of_activation_of_human_secondary_somatosensory_cortex_in_Unverricht_Lundborg_type_of_progressive_myoclonus_epilepsy_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=2001&volume=49&issue=1&spage=90 DB - PRIME DP - Unbound Medicine ER -