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[Acetyl starch as volume substitute, a possible alternative to HES].
Dtsch Med Wochenschr. 2001 Jan 05; 126(1-2):1-6.DM

Abstract

OBJECTIVES

Pharmacokinetics and tolerability of acetyl starch (ACS) in comparison to hydroxyethyl starch (HES) were investigated after repeated intravenous infusions. METHODS AND COHORTS: A 500 ml solution of ACS (n = 8) or HES (n = 9) was infused to male volunteers (Age 25-42 Years) over four hours on five consecutive days.

RESULTS

Comparing the pharmacokinetic parameters, marked differences were found between ACS and HES. A continuos increase of Cmax, AUC0-24 and t1/2 over the five days caused by administration of HES was due to an accumulation of HES in serum. However, after administration of ACS all these parameters remained unaltered. The repeated infusion of 50 g ACS did not cause any changes of the acid-base-status. The influence of ACS on the coagulation parameters was comparable to that of HES and due to dilution effects. The acetic acid concentration increased up to 2.96 +/- 0.67 mg/dl following ACS infusion. The blood glucose concentration was not influenced by the infusion of HES or of ACS. The repeated ACS infusions were well tolerated. In contrast to HES, ACS did not accumulate in serum.

CONCLUSION

According to these data ACS is an alternative to HES for volume replacement. Well-known side effects due to long storage of HES in tissues may not occur following application of ACS. However, the wide usage of ACS is restricted by the limited stability of ACS solutions at room temperature. ACS solutions are thus only stable during storage at lower temperatures.

Authors+Show Affiliations

Institut für Experimentelle Anästhesiologie, Johann Wolfgang Goethe-Universität, Frankfurt. asskali@em.uni-frankfurt.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

11200658

Citation

Asskali, F, et al. "[Acetyl Starch as Volume Substitute, a Possible Alternative to HES]." Deutsche Medizinische Wochenschrift (1946), vol. 126, no. 1-2, 2001, pp. 1-6.
Asskali F, Warnken U, Förster H. [Acetyl starch as volume substitute, a possible alternative to HES]. Dtsch Med Wochenschr. 2001;126(1-2):1-6.
Asskali, F., Warnken, U., & Förster, H. (2001). [Acetyl starch as volume substitute, a possible alternative to HES]. Deutsche Medizinische Wochenschrift (1946), 126(1-2), 1-6.
Asskali F, Warnken U, Förster H. [Acetyl Starch as Volume Substitute, a Possible Alternative to HES]. Dtsch Med Wochenschr. 2001 Jan 5;126(1-2):1-6. PubMed PMID: 11200658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acetyl starch as volume substitute, a possible alternative to HES]. AU - Asskali,F, AU - Warnken,U, AU - Förster,H, PY - 2001/2/24/pubmed PY - 2001/3/3/medline PY - 2001/2/24/entrez SP - 1 EP - 6 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 126 IS - 1-2 N2 - OBJECTIVES: Pharmacokinetics and tolerability of acetyl starch (ACS) in comparison to hydroxyethyl starch (HES) were investigated after repeated intravenous infusions. METHODS AND COHORTS: A 500 ml solution of ACS (n = 8) or HES (n = 9) was infused to male volunteers (Age 25-42 Years) over four hours on five consecutive days. RESULTS: Comparing the pharmacokinetic parameters, marked differences were found between ACS and HES. A continuos increase of Cmax, AUC0-24 and t1/2 over the five days caused by administration of HES was due to an accumulation of HES in serum. However, after administration of ACS all these parameters remained unaltered. The repeated infusion of 50 g ACS did not cause any changes of the acid-base-status. The influence of ACS on the coagulation parameters was comparable to that of HES and due to dilution effects. The acetic acid concentration increased up to 2.96 +/- 0.67 mg/dl following ACS infusion. The blood glucose concentration was not influenced by the infusion of HES or of ACS. The repeated ACS infusions were well tolerated. In contrast to HES, ACS did not accumulate in serum. CONCLUSION: According to these data ACS is an alternative to HES for volume replacement. Well-known side effects due to long storage of HES in tissues may not occur following application of ACS. However, the wide usage of ACS is restricted by the limited stability of ACS solutions at room temperature. ACS solutions are thus only stable during storage at lower temperatures. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/11200658/[Acetyl_starch_as_volume_substitute_a_possible_alternative_to_HES]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-9886 DB - PRIME DP - Unbound Medicine ER -