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[Analysis of dietary factors in Alzheimer's disease: clinical use of nutritional intervention for prevention and treatment of dementia].
Nihon Ronen Igakkai Zasshi 2000; 37(12):970-3NR

Abstract

To determine dietary factors involved in the pathological process of Alzheimer's disease (AD), we analyzed food consumption and intake of nutrients using Self-administered Diet History Questionnaire (DHQ) developed for Japanese. Sixty four AD patients and 80 age-matched healthy subjects were enrolled in this study. AD was diagnosed according to the criteria of DSM-IV. Dietary behaviors of AD patients was markedly deviated from those of age-matched healthy elderly. AD patients disliked fish and green-yellow vegetables and took more meats than controls. Energy-adjusted analysis of nutrients revealed that AD patients took less vitamin C and carotene. Most conspicuously, AD patients took significantly smaller amount of n-3 polyunsaturated fatty acid (PUFA) reflecting low consumption of fish, and their n-6/n-3 ratio was significantly increased. These habits started from 3 months to 44 years before the onset of dementia, suggesting these dietary abnormalities are not merely the consequence of dementia. Rather, it implies that AD might be a life style-related disease such as coronary heart disease, western style diet-associated cancer and hyperallergy. To see if cognitive function was improved by correcting the n-6/n-3 ratio, we prescribed eicossapentaenoic acid (EPA), one type of n-3 PUFA, for AD patients. Cognitive function was evaluated using MMSE. Administration of EPA (900 mg/day) improved MMSE significantly with maximal effects at 3 months and the effects lasted 6 months. However, the score of MMSE decreased after 6 months. The present study showed that nutritional intervention is useful for the prevention of AD, and also for the therapy of dementia, though it has some limitation.

Authors+Show Affiliations

Department of Neurology, Jichi Medical School, Omiya Medical Center.

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

11201186

Citation

Otsuka, M. "[Analysis of Dietary Factors in Alzheimer's Disease: Clinical Use of Nutritional Intervention for Prevention and Treatment of Dementia]." Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, vol. 37, no. 12, 2000, pp. 970-3.
Otsuka M. [Analysis of dietary factors in Alzheimer's disease: clinical use of nutritional intervention for prevention and treatment of dementia]. Nihon Ronen Igakkai Zasshi. 2000;37(12):970-3.
Otsuka, M. (2000). [Analysis of dietary factors in Alzheimer's disease: clinical use of nutritional intervention for prevention and treatment of dementia]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 37(12), pp. 970-3.
Otsuka M. [Analysis of Dietary Factors in Alzheimer's Disease: Clinical Use of Nutritional Intervention for Prevention and Treatment of Dementia]. Nihon Ronen Igakkai Zasshi. 2000;37(12):970-3. PubMed PMID: 11201186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Analysis of dietary factors in Alzheimer's disease: clinical use of nutritional intervention for prevention and treatment of dementia]. A1 - Otsuka,M, PY - 2001/2/24/pubmed PY - 2001/3/10/medline PY - 2001/2/24/entrez SP - 970 EP - 3 JF - Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics JO - Nihon Ronen Igakkai Zasshi VL - 37 IS - 12 N2 - To determine dietary factors involved in the pathological process of Alzheimer's disease (AD), we analyzed food consumption and intake of nutrients using Self-administered Diet History Questionnaire (DHQ) developed for Japanese. Sixty four AD patients and 80 age-matched healthy subjects were enrolled in this study. AD was diagnosed according to the criteria of DSM-IV. Dietary behaviors of AD patients was markedly deviated from those of age-matched healthy elderly. AD patients disliked fish and green-yellow vegetables and took more meats than controls. Energy-adjusted analysis of nutrients revealed that AD patients took less vitamin C and carotene. Most conspicuously, AD patients took significantly smaller amount of n-3 polyunsaturated fatty acid (PUFA) reflecting low consumption of fish, and their n-6/n-3 ratio was significantly increased. These habits started from 3 months to 44 years before the onset of dementia, suggesting these dietary abnormalities are not merely the consequence of dementia. Rather, it implies that AD might be a life style-related disease such as coronary heart disease, western style diet-associated cancer and hyperallergy. To see if cognitive function was improved by correcting the n-6/n-3 ratio, we prescribed eicossapentaenoic acid (EPA), one type of n-3 PUFA, for AD patients. Cognitive function was evaluated using MMSE. Administration of EPA (900 mg/day) improved MMSE significantly with maximal effects at 3 months and the effects lasted 6 months. However, the score of MMSE decreased after 6 months. The present study showed that nutritional intervention is useful for the prevention of AD, and also for the therapy of dementia, though it has some limitation. SN - 0300-9173 UR - https://www.unboundmedicine.com/medline/citation/11201186/[Analysis_of_dietary_factors_in_Alzheimer's_disease:_clinical_use_of_nutritional_intervention_for_prevention_and_treatment_of_dementia]_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/geriatrics1964/37.970?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -