Tags

Type your tag names separated by a space and hit enter

Allyl sulfides modify cell growth.
Drug Metabol Drug Interact. 2000; 17(1-4):81-107.DM

Abstract

Extensive evidence points to the ability of allyl sulfides from garlic to suppress tumor proliferation both in vitro and in vivo. This antineoplastic effect is generally greater for lipid-soluble than water-soluble allyl sulfides. Both concentration and duration of exposure can increase the antiproliferative effects of lipid- and water-soluble allyl sulfides. Part of their antiproliferative effects may relate to an increase in membrane fluidity and a suppression of integrin glycoprotein IIb-IIIa mediated adhesion. Alterations in cholesterol, arachidonic acid, phospholipids and/or thiols may account for these changes in membrane function. Allyl sulfides are also recognized for their ability to suppress cellular proliferation by blocking cells in the G2/M phase and by the induction of apoptosis. This increase in the G2/M and apoptotic cell populations correlates with depressed p34cdc2 kinase activity, increased histone acetylation, increased intracellular calcium and elevated cellular peroxide production. While impressive pre-clinical data exist about the antineoplastic effects of allyl sulfur compounds, considerably more attention needs to be given to their effects in humans. The composition of the entire diet and a host of genetic/epigenetic factors will likely determine the true benefits that might arise from allyl sulfur compounds from garlic and other Allium foods.

Authors+Show Affiliations

Nutrition Department, The Pennsylvania State University, University Park, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11201305

Citation

Knowles, L M., and J A. Milner. "Allyl Sulfides Modify Cell Growth." Drug Metabolism and Drug Interactions, vol. 17, no. 1-4, 2000, pp. 81-107.
Knowles LM, Milner JA. Allyl sulfides modify cell growth. Drug Metabol Drug Interact. 2000;17(1-4):81-107.
Knowles, L. M., & Milner, J. A. (2000). Allyl sulfides modify cell growth. Drug Metabolism and Drug Interactions, 17(1-4), 81-107.
Knowles LM, Milner JA. Allyl Sulfides Modify Cell Growth. Drug Metabol Drug Interact. 2000;17(1-4):81-107. PubMed PMID: 11201305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allyl sulfides modify cell growth. AU - Knowles,L M, AU - Milner,J A, PY - 2001/2/24/pubmed PY - 2001/3/10/medline PY - 2001/2/24/entrez SP - 81 EP - 107 JF - Drug metabolism and drug interactions JO - Drug Metabol Drug Interact VL - 17 IS - 1-4 N2 - Extensive evidence points to the ability of allyl sulfides from garlic to suppress tumor proliferation both in vitro and in vivo. This antineoplastic effect is generally greater for lipid-soluble than water-soluble allyl sulfides. Both concentration and duration of exposure can increase the antiproliferative effects of lipid- and water-soluble allyl sulfides. Part of their antiproliferative effects may relate to an increase in membrane fluidity and a suppression of integrin glycoprotein IIb-IIIa mediated adhesion. Alterations in cholesterol, arachidonic acid, phospholipids and/or thiols may account for these changes in membrane function. Allyl sulfides are also recognized for their ability to suppress cellular proliferation by blocking cells in the G2/M phase and by the induction of apoptosis. This increase in the G2/M and apoptotic cell populations correlates with depressed p34cdc2 kinase activity, increased histone acetylation, increased intracellular calcium and elevated cellular peroxide production. While impressive pre-clinical data exist about the antineoplastic effects of allyl sulfur compounds, considerably more attention needs to be given to their effects in humans. The composition of the entire diet and a host of genetic/epigenetic factors will likely determine the true benefits that might arise from allyl sulfur compounds from garlic and other Allium foods. SN - 0792-5077 UR - https://www.unboundmedicine.com/medline/citation/11201305/Allyl_sulfides_modify_cell_growth_ L2 - https://medlineplus.gov/cancerinchildren.html DB - PRIME DP - Unbound Medicine ER -