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Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment.
Menopause 2001 Jan-Feb; 8(1):17-26M

Abstract

OBJECTIVE

We examined the change in menopausal symptoms in response to 24 weeks of isoflavone-rich (80.4 mg/day) and isoflavone-poor (4.4 mg/day) soy protein isolate treatment in perimenopausal women.

DESIGN

In this double-blind 24-week study, 69 women were randomized to treatment: isoflavone-rich soy protein (n = 24), isoflavone-poor soy protein (n = 24), or whey protein control (n = 21). A Menopausal Index was used to assess change in hot flushes and night sweats, as well as other symptoms, at baseline, week 12, and week 24.

RESULTS

Repeated measures analysis of variance indicated no treatment effect on change in hot flush (p = 0.18) and night sweat (p = 0.92) frequency, whereas there was a significant decline in hot flush (p = 0.0003) and night sweat (p = 0.0007) frequency with time in all treatment groups. Chi2 analyses indicated no treatment effect on severity of hot flushes or night sweats at any time point, as well as no treatment effect on frequency or severity of other vasomotor symptoms. At the completion of the study, we found no treatment effect on retrospective perception of frequency, duration, or severity of hot flushes or night sweats. Since time had a significant effect on symptoms with all groups reporting a decline in overall symptoms, this indicated either a placebo effect or simply an improvement in symptoms during the study.

CONCLUSION

In this study, we found no evidence that isoflavone-rich or isoflavone-poor soy protein provided relief of vasomotor or of other menopausal symptoms.

Authors+Show Affiliations

Department of Food Science & Human Nutrition, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames 50011-1120. USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

11201510

Citation

St Germain, A, et al. "Isoflavone-rich or Isoflavone-poor Soy Protein Does Not Reduce Menopausal Symptoms During 24 Weeks of Treatment." Menopause (New York, N.Y.), vol. 8, no. 1, 2001, pp. 17-26.
St Germain A, Peterson CT, Robinson JG, et al. Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause. 2001;8(1):17-26.
St Germain, A., Peterson, C. T., Robinson, J. G., & Alekel, D. L. (2001). Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause (New York, N.Y.), 8(1), pp. 17-26.
St Germain A, et al. Isoflavone-rich or Isoflavone-poor Soy Protein Does Not Reduce Menopausal Symptoms During 24 Weeks of Treatment. Menopause. 2001;8(1):17-26. PubMed PMID: 11201510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. AU - St Germain,A, AU - Peterson,C T, AU - Robinson,J G, AU - Alekel,D L, PY - 2001/2/24/pubmed PY - 2001/3/17/medline PY - 2001/2/24/entrez SP - 17 EP - 26 JF - Menopause (New York, N.Y.) JO - Menopause VL - 8 IS - 1 N2 - OBJECTIVE: We examined the change in menopausal symptoms in response to 24 weeks of isoflavone-rich (80.4 mg/day) and isoflavone-poor (4.4 mg/day) soy protein isolate treatment in perimenopausal women. DESIGN: In this double-blind 24-week study, 69 women were randomized to treatment: isoflavone-rich soy protein (n = 24), isoflavone-poor soy protein (n = 24), or whey protein control (n = 21). A Menopausal Index was used to assess change in hot flushes and night sweats, as well as other symptoms, at baseline, week 12, and week 24. RESULTS: Repeated measures analysis of variance indicated no treatment effect on change in hot flush (p = 0.18) and night sweat (p = 0.92) frequency, whereas there was a significant decline in hot flush (p = 0.0003) and night sweat (p = 0.0007) frequency with time in all treatment groups. Chi2 analyses indicated no treatment effect on severity of hot flushes or night sweats at any time point, as well as no treatment effect on frequency or severity of other vasomotor symptoms. At the completion of the study, we found no treatment effect on retrospective perception of frequency, duration, or severity of hot flushes or night sweats. Since time had a significant effect on symptoms with all groups reporting a decline in overall symptoms, this indicated either a placebo effect or simply an improvement in symptoms during the study. CONCLUSION: In this study, we found no evidence that isoflavone-rich or isoflavone-poor soy protein provided relief of vasomotor or of other menopausal symptoms. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/11201510/Isoflavone_rich_or_isoflavone_poor_soy_protein_does_not_reduce_menopausal_symptoms_during_24_weeks_of_treatment_ L2 - http://dx.doi.org/10.1097/00042192-200101000-00005 DB - PRIME DP - Unbound Medicine ER -