Tags

Type your tag names separated by a space and hit enter

The role of Schwann cells, T cells and Mycobacterium leprae in the immunopathogenesis of nerve damage in leprosy.
Lepr Rev. 2000 Dec; 71 Suppl:S121-9.LR

Abstract

Damage to peripheral nerves is the major complication of reversal (type I) reactions in leprosy. The underlying mechanism of nerve damage remains largely unresolved; however, an important role for type-1 T cells has been suggested. Mycobacterium leprae has a remarkable tropism for the Schwann cells that surround peripheral axons. Because reversal reactions in leprosy are often accompanied by severe and irreversible nerve destruction, and are associated with increased cellular immune reactivity against M. leprae, a likely immunopathogenic mechanism of damage to Schwann cells and peripheral nerves in leprosy is that infected Schwann cells process and present antigens of M. leprae to antigen-specific, inflammatory, type-1 T cells, and that these T cells subsequently damage and lyse infected Schwann cells. Previous animal studies with CD8+ T cells revealed evidence for the existence of such a mechanism. A similar role has been suggested for CD4+ T cells. These latter cells may be more important in causing nerve damage in vivo, given the predilection of M. leprae for Schwann cells, and the dominant role of CD4+, serine esterase+ Th1 cells in the lesions of leprosy. Antagonism of the molecular interactions among M. leprae, Schwann cells and inflammatory T cells may therefore provide a rational strategy for prevention of damage of Schwann cell and nerves in leprosy.

Authors+Show Affiliations

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11201869

Citation

Spierings, E, et al. "The Role of Schwann Cells, T Cells and Mycobacterium Leprae in the Immunopathogenesis of Nerve Damage in Leprosy." Leprosy Review, vol. 71 Suppl, 2000, pp. S121-9.
Spierings E, De Boer T, Zulianello L, et al. The role of Schwann cells, T cells and Mycobacterium leprae in the immunopathogenesis of nerve damage in leprosy. Lepr Rev. 2000;71 Suppl:S121-9.
Spierings, E., De Boer, T., Zulianello, L., & Ottenhoff, T. H. (2000). The role of Schwann cells, T cells and Mycobacterium leprae in the immunopathogenesis of nerve damage in leprosy. Leprosy Review, 71 Suppl, S121-9.
Spierings E, et al. The Role of Schwann Cells, T Cells and Mycobacterium Leprae in the Immunopathogenesis of Nerve Damage in Leprosy. Lepr Rev. 2000;71 Suppl:S121-9. PubMed PMID: 11201869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of Schwann cells, T cells and Mycobacterium leprae in the immunopathogenesis of nerve damage in leprosy. AU - Spierings,E, AU - De Boer,T, AU - Zulianello,L, AU - Ottenhoff,T H, PY - 2001/2/24/pubmed PY - 2001/3/7/medline PY - 2001/2/24/entrez SP - S121 EP - 9 JF - Leprosy review JO - Lepr Rev VL - 71 Suppl N2 - Damage to peripheral nerves is the major complication of reversal (type I) reactions in leprosy. The underlying mechanism of nerve damage remains largely unresolved; however, an important role for type-1 T cells has been suggested. Mycobacterium leprae has a remarkable tropism for the Schwann cells that surround peripheral axons. Because reversal reactions in leprosy are often accompanied by severe and irreversible nerve destruction, and are associated with increased cellular immune reactivity against M. leprae, a likely immunopathogenic mechanism of damage to Schwann cells and peripheral nerves in leprosy is that infected Schwann cells process and present antigens of M. leprae to antigen-specific, inflammatory, type-1 T cells, and that these T cells subsequently damage and lyse infected Schwann cells. Previous animal studies with CD8+ T cells revealed evidence for the existence of such a mechanism. A similar role has been suggested for CD4+ T cells. These latter cells may be more important in causing nerve damage in vivo, given the predilection of M. leprae for Schwann cells, and the dominant role of CD4+, serine esterase+ Th1 cells in the lesions of leprosy. Antagonism of the molecular interactions among M. leprae, Schwann cells and inflammatory T cells may therefore provide a rational strategy for prevention of damage of Schwann cell and nerves in leprosy. SN - 0305-7518 UR - https://www.unboundmedicine.com/medline/citation/11201869/The_role_of_Schwann_cells_T_cells_and_Mycobacterium_leprae_in_the_immunopathogenesis_of_nerve_damage_in_leprosy_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -