Tags

Type your tag names separated by a space and hit enter

The extent of duodenogastric reflux in gastro-oesophageal reflux disease.
Eur J Gastroenterol Hepatol. 2001 Jan; 13(1):5-10.EJ

Abstract

BACKGROUND

It is known that duodenogastro-oesophageal reflux (DGOR) increases with worsening gastro-oesophageal reflux disease (GORD). It is unclear whether this is accompanied by increasing duodenogastric reflux (DGR).

OBJECTIVE

To investigate the extent of DGR in a control group and 66 patients with GORD, using the technique of ambulatory gastric bilirubin monitoring.

METHODS

Sixty-six patients with reflux symptoms (30 grade 0 or 1 oesophagitis (group 1), 16 grade 2 or 3 oesophagitis (group 2), 20 Barrett's oesophagus (group 3)) and 17 healthy controls were studied. All underwent oesophageal manometry followed by 24-h ambulatory oesophageal and gastric pH monitoring and gastric bilirubin monitoring.

RESULTS

Median per cent total oesophageal acid exposure (pH < 4) was significantly less in the control group (0.6%) than in group 1 (2.8%, P< 0.05) and groups 2 and 3 (7.5% and 7.8% respectively, P< 0.001). There was no significant difference between any group in median per cent total time gastric pH was greater than 4. There was no significant difference in median per cent total gastric bilirubin exposure (absorbance > 0.14) between any group. However, in each group gastric bilirubin exposure was greater in the supine position than the upright position, being significantly greater in the control group (P< 0.05) and group 1 (P < 0.001).

CONCLUSIONS

Gastric bilirubin exposure is similar across the spectrum of GORD severity. It is greater in the supine than in the upright position.

Authors+Show Affiliations

Department of Surgery, Guy's Hospital, London, UK. bobandtup@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11204810

Citation

Marshall, R E., et al. "The Extent of Duodenogastric Reflux in Gastro-oesophageal Reflux Disease." European Journal of Gastroenterology & Hepatology, vol. 13, no. 1, 2001, pp. 5-10.
Marshall RE, Anggiansah A, Owen WA, et al. The extent of duodenogastric reflux in gastro-oesophageal reflux disease. Eur J Gastroenterol Hepatol. 2001;13(1):5-10.
Marshall, R. E., Anggiansah, A., Owen, W. A., Manifold, D. K., & Owen, W. J. (2001). The extent of duodenogastric reflux in gastro-oesophageal reflux disease. European Journal of Gastroenterology & Hepatology, 13(1), 5-10.
Marshall RE, et al. The Extent of Duodenogastric Reflux in Gastro-oesophageal Reflux Disease. Eur J Gastroenterol Hepatol. 2001;13(1):5-10. PubMed PMID: 11204810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The extent of duodenogastric reflux in gastro-oesophageal reflux disease. AU - Marshall,R E, AU - Anggiansah,A, AU - Owen,W A, AU - Manifold,D K, AU - Owen,W J, PY - 2001/2/24/pubmed PY - 2001/4/3/medline PY - 2001/2/24/entrez SP - 5 EP - 10 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 13 IS - 1 N2 - BACKGROUND: It is known that duodenogastro-oesophageal reflux (DGOR) increases with worsening gastro-oesophageal reflux disease (GORD). It is unclear whether this is accompanied by increasing duodenogastric reflux (DGR). OBJECTIVE: To investigate the extent of DGR in a control group and 66 patients with GORD, using the technique of ambulatory gastric bilirubin monitoring. METHODS: Sixty-six patients with reflux symptoms (30 grade 0 or 1 oesophagitis (group 1), 16 grade 2 or 3 oesophagitis (group 2), 20 Barrett's oesophagus (group 3)) and 17 healthy controls were studied. All underwent oesophageal manometry followed by 24-h ambulatory oesophageal and gastric pH monitoring and gastric bilirubin monitoring. RESULTS: Median per cent total oesophageal acid exposure (pH < 4) was significantly less in the control group (0.6%) than in group 1 (2.8%, P< 0.05) and groups 2 and 3 (7.5% and 7.8% respectively, P< 0.001). There was no significant difference between any group in median per cent total time gastric pH was greater than 4. There was no significant difference in median per cent total gastric bilirubin exposure (absorbance > 0.14) between any group. However, in each group gastric bilirubin exposure was greater in the supine position than the upright position, being significantly greater in the control group (P< 0.05) and group 1 (P < 0.001). CONCLUSIONS: Gastric bilirubin exposure is similar across the spectrum of GORD severity. It is greater in the supine than in the upright position. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/11204810/The_extent_of_duodenogastric_reflux_in_gastro_oesophageal_reflux_disease_ L2 - http://dx.doi.org/10.1097/00042737-200101000-00002 DB - PRIME DP - Unbound Medicine ER -