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Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity.

Abstract

AIMS/HYPOTHESIS

This study aimed to establish the relation between early infant nutrition and signs of beta-cell autoimmunity in young children.

METHODS

We identified and observed from birth 2949 infants with increased genetic risk of Type I (insulin-dependent) diabetes mellitus (HLA DQB1*02/ *0302 or DQB1*0302/x, x = other than *02, *0301 or *0602) and monitored them for islet cell antibodies at 3 to 6 month intervals. If an infant seroconverted to islet cell antibody positivity, all of his or her samples were also analysed for autoantibodies to insulin, GAD65 (GADA) and to the protein tyrosine phosphatase related IA-2 molecule (IA-2A). Our case-control study comprises the first 65 children who seroconverted to islet cell antibody positivity before the age of 4 years and 390 control children who were islet cell antibody-negative (six control children/ case). We monitored the duration of exclusive and total breastfeeding and the age at which cows' milk was introduced.

RESULTS

Infants who had been breastfed exclusively for at least 4 months had lower risk of seroconversion to positivity for IA-2A or all four autoantibodies [odds ratio (OR) 0.24; 95 % CI 0.06-0.94 and OR 0.17; 95 % CI 0.03-0.86, respectively] than those infants who had been breastfed exclusively for less than 2 months. The risk of seroconversion to positivity for IA-2A or all four autoantibodies was higher in those younger than 2 months (OR 4.37; 95 % CI 1.33-14.42 and OR 5.02; 95 % CI 1.27-19.89) or aged 2 to 3.9 months (OR 5.50; 95 % CI 1.21-25.04 and 6.19; 95% CI 1.10-34.84) when they first received cows' milk than in those aged 4 months or older.

CONCLUSIONS/INTERPRETATION

These observations suggest that short-term breastfeeding and the early introduction of cows' milk-based infant formula predispose young children who are genetically susceptible to Type I diabetes to progressive signs of beta-cell autoimmunity.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Tampere University Hospital, Finland.

    , , , , , ,

    Source

    Diabetologia 44:1 2001 Jan pg 63-9

    MeSH

    Aging
    Animals
    Autoantibodies
    Autoimmunity
    Breast Feeding
    Case-Control Studies
    Diabetes Mellitus, Type 1
    Genetic Predisposition to Disease
    Glutamate Decarboxylase
    HLA-DQ Antigens
    HLA-DQ beta-Chains
    Humans
    Infant
    Infant Food
    Infant Nutritional Physiological Phenomena
    Insulin
    Islets of Langerhans
    Milk
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11206413

    Citation

    Kimpimäki, T, et al. "Short-term Exclusive Breastfeeding Predisposes Young Children With Increased Genetic Risk of Type I Diabetes to Progressive Beta-cell Autoimmunity." Diabetologia, vol. 44, no. 1, 2001, pp. 63-9.
    Kimpimäki T, Erkkola M, Korhonen S, et al. Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity. Diabetologia. 2001;44(1):63-9.
    Kimpimäki, T., Erkkola, M., Korhonen, S., Kupila, A., Virtanen, S. M., Ilonen, J., ... Knip, M. (2001). Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity. Diabetologia, 44(1), pp. 63-9.
    Kimpimäki T, et al. Short-term Exclusive Breastfeeding Predisposes Young Children With Increased Genetic Risk of Type I Diabetes to Progressive Beta-cell Autoimmunity. Diabetologia. 2001;44(1):63-9. PubMed PMID: 11206413.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity. AU - Kimpimäki,T, AU - Erkkola,M, AU - Korhonen,S, AU - Kupila,A, AU - Virtanen,S M, AU - Ilonen,J, AU - Simell,O, AU - Knip,M, PY - 2001/2/24/pubmed PY - 2001/3/17/medline PY - 2001/2/24/entrez SP - 63 EP - 9 JF - Diabetologia JO - Diabetologia VL - 44 IS - 1 N2 - AIMS/HYPOTHESIS: This study aimed to establish the relation between early infant nutrition and signs of beta-cell autoimmunity in young children. METHODS: We identified and observed from birth 2949 infants with increased genetic risk of Type I (insulin-dependent) diabetes mellitus (HLA DQB1*02/ *0302 or DQB1*0302/x, x = other than *02, *0301 or *0602) and monitored them for islet cell antibodies at 3 to 6 month intervals. If an infant seroconverted to islet cell antibody positivity, all of his or her samples were also analysed for autoantibodies to insulin, GAD65 (GADA) and to the protein tyrosine phosphatase related IA-2 molecule (IA-2A). Our case-control study comprises the first 65 children who seroconverted to islet cell antibody positivity before the age of 4 years and 390 control children who were islet cell antibody-negative (six control children/ case). We monitored the duration of exclusive and total breastfeeding and the age at which cows' milk was introduced. RESULTS: Infants who had been breastfed exclusively for at least 4 months had lower risk of seroconversion to positivity for IA-2A or all four autoantibodies [odds ratio (OR) 0.24; 95 % CI 0.06-0.94 and OR 0.17; 95 % CI 0.03-0.86, respectively] than those infants who had been breastfed exclusively for less than 2 months. The risk of seroconversion to positivity for IA-2A or all four autoantibodies was higher in those younger than 2 months (OR 4.37; 95 % CI 1.33-14.42 and OR 5.02; 95 % CI 1.27-19.89) or aged 2 to 3.9 months (OR 5.50; 95 % CI 1.21-25.04 and 6.19; 95% CI 1.10-34.84) when they first received cows' milk than in those aged 4 months or older. CONCLUSIONS/INTERPRETATION: These observations suggest that short-term breastfeeding and the early introduction of cows' milk-based infant formula predispose young children who are genetically susceptible to Type I diabetes to progressive signs of beta-cell autoimmunity. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/11206413/Short_term_exclusive_breastfeeding_predisposes_young_children_with_increased_genetic_risk_of_Type_I_diabetes_to_progressive_beta_cell_autoimmunity_ L2 - https://dx.doi.org/10.1007/s001250051581 DB - PRIME DP - Unbound Medicine ER -