Tags

Type your tag names separated by a space and hit enter

Hormonal characteristics of the human menstrual cycle throughout reproductive life.
J Clin Invest. 1975 Apr; 55(4):699-706.JCI

Abstract

The changes in serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FHS), estradiol, and progesterone that occur both early and late in reproductive life were characterized and compared with findings in young, normal women and in patients with certain menstrual disorders. A total of 50 complete menstrual cycles in 37 were examined. Five distinct patterns of hormonal regulation were found, three of which are reported here: (a) A long follicular phase and delayed follicular maturation in young women with long, unpredictable intermenstrual intervals from menarche; (b) a short follicular phase with increasing age and in short cycles in perimenopausal women; and (c) true anovulatory vaginal bleeding in long cycles in perimenopausal women. The short cycles before and during the menopausal transition were found to have lower E2 levels and high FSH concentrations throughout, while LH remained in the normal range. During long cycles in perimenopausal women, concentrations of LH and FSH were in the menopausal range. However, follicular maturation was observed months after high levels of gonadotropins were attained. These studies permit the characterization of the menstrual history of the normal woman in terms of the hormonal changes that occur and provide a basis for the definition of several disorders of follicular maturation.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1120778

Citation

Sherman, B M., and S G. Korenman. "Hormonal Characteristics of the Human Menstrual Cycle Throughout Reproductive Life." The Journal of Clinical Investigation, vol. 55, no. 4, 1975, pp. 699-706.
Sherman BM, Korenman SG. Hormonal characteristics of the human menstrual cycle throughout reproductive life. J Clin Invest. 1975;55(4):699-706.
Sherman, B. M., & Korenman, S. G. (1975). Hormonal characteristics of the human menstrual cycle throughout reproductive life. The Journal of Clinical Investigation, 55(4), 699-706.
Sherman BM, Korenman SG. Hormonal Characteristics of the Human Menstrual Cycle Throughout Reproductive Life. J Clin Invest. 1975;55(4):699-706. PubMed PMID: 1120778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal characteristics of the human menstrual cycle throughout reproductive life. AU - Sherman,B M, AU - Korenman,S G, PY - 1975/4/1/pubmed PY - 1975/4/1/medline PY - 1975/4/1/entrez SP - 699 EP - 706 JF - The Journal of clinical investigation JO - J Clin Invest VL - 55 IS - 4 N2 - The changes in serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FHS), estradiol, and progesterone that occur both early and late in reproductive life were characterized and compared with findings in young, normal women and in patients with certain menstrual disorders. A total of 50 complete menstrual cycles in 37 were examined. Five distinct patterns of hormonal regulation were found, three of which are reported here: (a) A long follicular phase and delayed follicular maturation in young women with long, unpredictable intermenstrual intervals from menarche; (b) a short follicular phase with increasing age and in short cycles in perimenopausal women; and (c) true anovulatory vaginal bleeding in long cycles in perimenopausal women. The short cycles before and during the menopausal transition were found to have lower E2 levels and high FSH concentrations throughout, while LH remained in the normal range. During long cycles in perimenopausal women, concentrations of LH and FSH were in the menopausal range. However, follicular maturation was observed months after high levels of gonadotropins were attained. These studies permit the characterization of the menstrual history of the normal woman in terms of the hormonal changes that occur and provide a basis for the definition of several disorders of follicular maturation. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/1120778/Hormonal_characteristics_of_the_human_menstrual_cycle_throughout_reproductive_life_ L2 - https://doi.org/10.1172/JCI107979 DB - PRIME DP - Unbound Medicine ER -