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Correction of hypertensive cardiac remodelling: comparison of different antihypertensive therapies.
Med Sci Monit. 2000 Mar-Apr; 6(2):309-13.MS

Abstract

The aim of the study was to compare the effects of long-term treatment with different types of antihypertensive drugs on left ventricular hypertrophy (LVH) and diastolic function in patients with essential hypertension. We examined 60 patients with mild to moderate hypertension from 35 to 55 years old (middle age 44.3 +/- 2.3 yrs) having no concomitant diseases. Patients were treated for six months with different types of antihypertensive drugs: 21 patient received nifedipine-retard 40 mg/day, 20--atenolol 100 mg/day, 10--losartan potassium 100 mg/day, 9--perindopril 4 mg/day. Cardiac structure and function was studied by echocardiography. For the left ventricle (LV) the diastolic mass normalised for body surface area (LVMI), the ratio of the early and atrial mitral inflow velocities (E/A), isovolumetric relaxation time (IVRT), relative wall thickness (RWT) were measured. After six months of treatment LVMI decreased by 9% in nifedipine group (P < 0.01), by 10.5% in atenolol group (P < 0.01), by 12% in losartan group (P < 0.01) and by 8.2% in perindopril group (NS). RWT decreased in all groups, while diastolic dimension index remained unchanged. The reversal of LVH was not related to blood pressure reduction. It was more significant in patients with initially higher values of LVMI. Antihypertensive effects of the drugs were comparable. Long-term treatment with all types of selected drugs improves cardiac structure and function independently of their antihypertensive action. Our data suggest that on the basis of the influence on cardiac remodelling no preference for any studied drug can be discerned. The work had the following source of support: the atenolol (Falitonsin) and nifedipine-retard (Corinfar-retard) were provided by the AWD Company (Germany), losartan potassium has been provided by Merck Sharp & Dohme Company and perindopril (Prestarium) by the Servier Group.

Authors+Show Affiliations

Faculty Therapy Dept., St. Petersburg Pavlov State Medical University, 6/8 Lev Tołstoy str., St. Petersburg 197089, Russia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11208328

Citation

Almazov, V A., et al. "Correction of Hypertensive Cardiac Remodelling: Comparison of Different Antihypertensive Therapies." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 6, no. 2, 2000, pp. 309-13.
Almazov VA, Shlyakhto EV, Konrady AO, et al. Correction of hypertensive cardiac remodelling: comparison of different antihypertensive therapies. Med Sci Monit. 2000;6(2):309-13.
Almazov, V. A., Shlyakhto, E. V., Konrady, A. O., Macsimova, T. A., Zaharov, D. V., & Rudomanov, O. G. (2000). Correction of hypertensive cardiac remodelling: comparison of different antihypertensive therapies. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 6(2), 309-13.
Almazov VA, et al. Correction of Hypertensive Cardiac Remodelling: Comparison of Different Antihypertensive Therapies. Med Sci Monit. 2000 Mar-Apr;6(2):309-13. PubMed PMID: 11208328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correction of hypertensive cardiac remodelling: comparison of different antihypertensive therapies. AU - Almazov,V A, AU - Shlyakhto,E V, AU - Konrady,A O, AU - Macsimova,T A, AU - Zaharov,D V, AU - Rudomanov,O G, PY - 2001/2/24/pubmed PY - 2001/10/12/medline PY - 2001/2/24/entrez SP - 309 EP - 13 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 6 IS - 2 N2 - The aim of the study was to compare the effects of long-term treatment with different types of antihypertensive drugs on left ventricular hypertrophy (LVH) and diastolic function in patients with essential hypertension. We examined 60 patients with mild to moderate hypertension from 35 to 55 years old (middle age 44.3 +/- 2.3 yrs) having no concomitant diseases. Patients were treated for six months with different types of antihypertensive drugs: 21 patient received nifedipine-retard 40 mg/day, 20--atenolol 100 mg/day, 10--losartan potassium 100 mg/day, 9--perindopril 4 mg/day. Cardiac structure and function was studied by echocardiography. For the left ventricle (LV) the diastolic mass normalised for body surface area (LVMI), the ratio of the early and atrial mitral inflow velocities (E/A), isovolumetric relaxation time (IVRT), relative wall thickness (RWT) were measured. After six months of treatment LVMI decreased by 9% in nifedipine group (P < 0.01), by 10.5% in atenolol group (P < 0.01), by 12% in losartan group (P < 0.01) and by 8.2% in perindopril group (NS). RWT decreased in all groups, while diastolic dimension index remained unchanged. The reversal of LVH was not related to blood pressure reduction. It was more significant in patients with initially higher values of LVMI. Antihypertensive effects of the drugs were comparable. Long-term treatment with all types of selected drugs improves cardiac structure and function independently of their antihypertensive action. Our data suggest that on the basis of the influence on cardiac remodelling no preference for any studied drug can be discerned. The work had the following source of support: the atenolol (Falitonsin) and nifedipine-retard (Corinfar-retard) were provided by the AWD Company (Germany), losartan potassium has been provided by Merck Sharp & Dohme Company and perindopril (Prestarium) by the Servier Group. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/11208328/Correction_of_hypertensive_cardiac_remodelling:_comparison_of_different_antihypertensive_therapies_ L2 - https://www.medscimonit.com/download/index/idArt/508440 DB - PRIME DP - Unbound Medicine ER -