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Pathogenesis of ascites in cirrhosis and portal hypertension.
Med Sci Monit. 2000 Jul-Aug; 6(4):807-16.MS

Abstract

Disturbance of the circulatory system frequently occurs in patients with cirrhosis. Cardiac index and plasma volume increase whereas mean arterial blood pressure and systemic vascular resistance decrease. Marked disturbance in vasoconstrictor and natriuretic systems also exist with activation mediators such as plasma renin, plasma noradrenaline, antidiuretic hormone and endothelin. Renal factors contribute to the pathogenesis of ascites formation although the exact mechanisms are yet to be elucidated. Several theories exist in relation to pathogenesis although none to date fully explain all of the findings observed in clinical practice. In this review, we examine the mechanisms that contribute to the development of ascites in patients with cirrhosis and portal hypertension.

Authors+Show Affiliations

Heneghan MA
Academic Department of Hepatology, Institute of Liver Studies, King's College Hospital, Denmark Hill, London SE5 9PJ, England.
Harrison PM
No affiliation info available

MeSH

ArteriesAscitesBlood VolumeDiuresisHeartHemodynamicsHepatorenal SyndromeHumansHypertension, PortalKidneyLiver CirrhosisLungModels, BiologicalNatriuresisRenal CirculationVasoconstriction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11208415

Citation

Heneghan, M A., and P M. Harrison. "Pathogenesis of Ascites in Cirrhosis and Portal Hypertension." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 6, no. 4, 2000, pp. 807-16.
Heneghan MA, Harrison PM. Pathogenesis of ascites in cirrhosis and portal hypertension. Med Sci Monit. 2000;6(4):807-16.
Heneghan, M. A., & Harrison, P. M. (2000). Pathogenesis of ascites in cirrhosis and portal hypertension. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 6(4), 807-16.
Heneghan MA, Harrison PM. Pathogenesis of Ascites in Cirrhosis and Portal Hypertension. Med Sci Monit. 2000 Jul-Aug;6(4):807-16. PubMed PMID: 11208415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis of ascites in cirrhosis and portal hypertension. AU - Heneghan,M A, AU - Harrison,P M, PY - 2001/2/24/pubmed PY - 2001/4/6/medline PY - 2001/2/24/entrez SP - 807 EP - 16 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 6 IS - 4 N2 - Disturbance of the circulatory system frequently occurs in patients with cirrhosis. Cardiac index and plasma volume increase whereas mean arterial blood pressure and systemic vascular resistance decrease. Marked disturbance in vasoconstrictor and natriuretic systems also exist with activation mediators such as plasma renin, plasma noradrenaline, antidiuretic hormone and endothelin. Renal factors contribute to the pathogenesis of ascites formation although the exact mechanisms are yet to be elucidated. Several theories exist in relation to pathogenesis although none to date fully explain all of the findings observed in clinical practice. In this review, we examine the mechanisms that contribute to the development of ascites in patients with cirrhosis and portal hypertension. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/11208415/Pathogenesis_of_ascites_in_cirrhosis_and_portal_hypertension_ DB - PRIME DP - Unbound Medicine ER -