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Role of cytokines in pathogenesis of endometriosis.
Med Sci Monit 2000 Sep-Oct; 6(5):1042-6MS

Abstract

Sampson's theory stating that endometrial cells and fragments desquamate during the menstrual period are transported through Fallopian tubes into the peritoneal cavity where they implant, proliferate and develop into endometriotic lesions is generally accepted [1]. Accumulating data suggest that deficient immunity against retrograde endometrium during menstruation may be involved in the pathophysiology of endometriosis. Recent studies in women with endometriosis have demonstrated functional changes in several immunologic components in the peritoneal fluid as well as in sera of those patients. It was shown, for instance, that a wide pattern of cytokines are involved during endometrial cells implantation, proliferation and forming of endometriotic lesions. Those factors play a critical role in decreased immunologic surveillance, recognition and destruction of ectopic endometrial cells and possible facilitation of the implantation of ectopic endometrial tissues. The present review summarises the current knowledge on the role of different cytokines in the pathophysiology of endometriosis.

Authors+Show Affiliations

1st Department of Obstetric and Gynaecology, Medical University, Pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11208452

Citation

Barcz, E, et al. "Role of Cytokines in Pathogenesis of Endometriosis." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 6, no. 5, 2000, pp. 1042-6.
Barcz E, Kamiński P, Marianowski L. Role of cytokines in pathogenesis of endometriosis. Med Sci Monit. 2000;6(5):1042-6.
Barcz, E., Kamiński, P., & Marianowski, L. (2000). Role of cytokines in pathogenesis of endometriosis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 6(5), pp. 1042-6.
Barcz E, Kamiński P, Marianowski L. Role of Cytokines in Pathogenesis of Endometriosis. Med Sci Monit. 2000;6(5):1042-6. PubMed PMID: 11208452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of cytokines in pathogenesis of endometriosis. AU - Barcz,E, AU - Kamiński,P, AU - Marianowski,L, PY - 2001/2/24/pubmed PY - 2001/4/6/medline PY - 2001/2/24/entrez SP - 1042 EP - 6 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 6 IS - 5 N2 - Sampson's theory stating that endometrial cells and fragments desquamate during the menstrual period are transported through Fallopian tubes into the peritoneal cavity where they implant, proliferate and develop into endometriotic lesions is generally accepted [1]. Accumulating data suggest that deficient immunity against retrograde endometrium during menstruation may be involved in the pathophysiology of endometriosis. Recent studies in women with endometriosis have demonstrated functional changes in several immunologic components in the peritoneal fluid as well as in sera of those patients. It was shown, for instance, that a wide pattern of cytokines are involved during endometrial cells implantation, proliferation and forming of endometriotic lesions. Those factors play a critical role in decreased immunologic surveillance, recognition and destruction of ectopic endometrial cells and possible facilitation of the implantation of ectopic endometrial tissues. The present review summarises the current knowledge on the role of different cytokines in the pathophysiology of endometriosis. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/11208452/Role_of_cytokines_in_pathogenesis_of_endometriosis_ L2 - https://www.medscimonit.com/download/index/idArt/508076 DB - PRIME DP - Unbound Medicine ER -