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Chlorogenic acid and caffeic acid are absorbed in humans.
J Nutr. 2001 Jan; 131(1):66-71.JN

Abstract

Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee; daily intake in coffee drinkers is 0.5-1 g. Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of cardiovascular disease. However, data on the absorption of chlorogenic acid and caffeic acid in humans are lacking. We determined the absorption of chlorogenic acid and caffeic acid in a cross-over study with 4 female and 3 male healthy ileostomy subjects. In such subjects, degradation by the colonic microflora is minimal and absorption can be calculated as the amount ingested minus the amount excreted in ileostomy effluent. The ileostomy subjects ingested 2.8 mmol chlorogenic acid and 2.8 mmol caffeic acid on separate days in random order and subsequently collected ileostomy fluid and urine for 24 h. Absorption of chlorogenic acid was 33 +/- 17% (mean +/- SD) and of caffeic acid 95 +/- 4%. Traces of the ingested chlorogenic acid and 11% of the ingested caffeic acid were excreted in urine. Thus, one third of chlorogenic acid and almost all of the caffeic acid were absorbed in the small intestine of humans. This implies that part of chlorogenic acid from foods will enter into the blood circulation, but most will reach the colon.

Authors+Show Affiliations

Division of Human Nutrition and Epidemiology, Wageningen University, 6700 EV Wageningen, The Netherlands. margreet. olthof@staff.nutepi.wau.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11208940

Citation

Olthof, M R., et al. "Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans." The Journal of Nutrition, vol. 131, no. 1, 2001, pp. 66-71.
Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 2001;131(1):66-71.
Olthof, M. R., Hollman, P. C., & Katan, M. B. (2001). Chlorogenic acid and caffeic acid are absorbed in humans. The Journal of Nutrition, 131(1), 66-71.
Olthof MR, Hollman PC, Katan MB. Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans. J Nutr. 2001;131(1):66-71. PubMed PMID: 11208940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlorogenic acid and caffeic acid are absorbed in humans. AU - Olthof,M R, AU - Hollman,P C, AU - Katan,M B, PY - 2001/2/24/pubmed PY - 2001/6/2/medline PY - 2001/2/24/entrez SP - 66 EP - 71 JF - The Journal of nutrition JO - J Nutr VL - 131 IS - 1 N2 - Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee; daily intake in coffee drinkers is 0.5-1 g. Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of cardiovascular disease. However, data on the absorption of chlorogenic acid and caffeic acid in humans are lacking. We determined the absorption of chlorogenic acid and caffeic acid in a cross-over study with 4 female and 3 male healthy ileostomy subjects. In such subjects, degradation by the colonic microflora is minimal and absorption can be calculated as the amount ingested minus the amount excreted in ileostomy effluent. The ileostomy subjects ingested 2.8 mmol chlorogenic acid and 2.8 mmol caffeic acid on separate days in random order and subsequently collected ileostomy fluid and urine for 24 h. Absorption of chlorogenic acid was 33 +/- 17% (mean +/- SD) and of caffeic acid 95 +/- 4%. Traces of the ingested chlorogenic acid and 11% of the ingested caffeic acid were excreted in urine. Thus, one third of chlorogenic acid and almost all of the caffeic acid were absorbed in the small intestine of humans. This implies that part of chlorogenic acid from foods will enter into the blood circulation, but most will reach the colon. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11208940/Chlorogenic_acid_and_caffeic_acid_are_absorbed_in_humans_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.1.66 DB - PRIME DP - Unbound Medicine ER -