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Effects of modafinil in children with attention-deficit/hyperactivity disorder: an open-label study.
J Am Acad Child Adolesc Psychiatry. 2001 Feb; 40(2):230-5.JA

Abstract

OBJECTIVE

To examine the effect of once-daily dosing of modafinil, a stimulant that has a long duration of action, on clinical features of attention-deficit/hyperactivity disorder (ADHD) in children.

METHOD

An open-label design was used to compare the Conners Parent and Teacher Rating Scale-Revised (L) (CPRS, CTRS), the ADHD Rating Scale-IV, and the Test of Variables of Attention (TOVA), without and with medication, in children with ADHD. Eleven children with ADHD, ranging in age from 5 to 15 years, took modafinil for an average of 4.6 weeks.

RESULTS

Average TOVA ADHD scores improved by 2.43 SD (p = .0009). CTRS and CPRS ADHD index T scores improved by an average of 14.1 (p = .0009) and 17.7 points (p = .001), respectively. The mean ADHD Rating Scale-IV scores improved from the 88th percentile to the 75th percentile (p = .047). One subject withdrew from the study because of an adverse event that was resolved completely with medication withdrawal. Other side effects were mild and responded to dose adjustment. No subjects required more than one dose per day.

CONCLUSIONS

Modafinil may be a useful once-daily treatment for children with ADHD. Further study using a double-blind, placebo-controlled design is needed.

Authors+Show Affiliations

Department of Pediatrics, Helping Hands Development Center, Marshall University School of Medicine, Huntington, WV, USA. rugino@marshall.eduNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

11211372

Citation

Rugino, T A., and T C. Copley. "Effects of Modafinil in Children With Attention-deficit/hyperactivity Disorder: an Open-label Study." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 40, no. 2, 2001, pp. 230-5.
Rugino TA, Copley TC. Effects of modafinil in children with attention-deficit/hyperactivity disorder: an open-label study. J Am Acad Child Adolesc Psychiatry. 2001;40(2):230-5.
Rugino, T. A., & Copley, T. C. (2001). Effects of modafinil in children with attention-deficit/hyperactivity disorder: an open-label study. Journal of the American Academy of Child and Adolescent Psychiatry, 40(2), 230-5.
Rugino TA, Copley TC. Effects of Modafinil in Children With Attention-deficit/hyperactivity Disorder: an Open-label Study. J Am Acad Child Adolesc Psychiatry. 2001;40(2):230-5. PubMed PMID: 11211372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of modafinil in children with attention-deficit/hyperactivity disorder: an open-label study. AU - Rugino,T A, AU - Copley,T C, PY - 2001/2/24/pubmed PY - 2001/3/10/medline PY - 2001/2/24/entrez SP - 230 EP - 5 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 40 IS - 2 N2 - OBJECTIVE: To examine the effect of once-daily dosing of modafinil, a stimulant that has a long duration of action, on clinical features of attention-deficit/hyperactivity disorder (ADHD) in children. METHOD: An open-label design was used to compare the Conners Parent and Teacher Rating Scale-Revised (L) (CPRS, CTRS), the ADHD Rating Scale-IV, and the Test of Variables of Attention (TOVA), without and with medication, in children with ADHD. Eleven children with ADHD, ranging in age from 5 to 15 years, took modafinil for an average of 4.6 weeks. RESULTS: Average TOVA ADHD scores improved by 2.43 SD (p = .0009). CTRS and CPRS ADHD index T scores improved by an average of 14.1 (p = .0009) and 17.7 points (p = .001), respectively. The mean ADHD Rating Scale-IV scores improved from the 88th percentile to the 75th percentile (p = .047). One subject withdrew from the study because of an adverse event that was resolved completely with medication withdrawal. Other side effects were mild and responded to dose adjustment. No subjects required more than one dose per day. CONCLUSIONS: Modafinil may be a useful once-daily treatment for children with ADHD. Further study using a double-blind, placebo-controlled design is needed. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/11211372/Effects_of_modafinil_in_children_with_attention_deficit/hyperactivity_disorder:_an_open_label_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)60373-7 DB - PRIME DP - Unbound Medicine ER -