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Impaired glucose metabolism and obesity in Swedish patients with borderline isolated systolic hypertension: Skaraborg Hypertension and Diabetes Project.

Abstract

AIM

To assess the prevalence of borderline isolated systolic hypertension (borderline ISH), and to examine its association with other cardiovascular risk factors.

METHODS

A cross-sectional community-based study was carried out in 1993-1994 in Skara, Sweden, including 1109 randomly chosen subjects > or = 40 years old. Normotension (NT) was defined as systolic blood pressure (SBP) < 140 and diastolic blood pressure (DBP) < 90 mmHg, borderline ISH as SBP 140-159 and DBP < 90 mmHg and hypertension (HT) as SBP > or = 160 or DBP > or = 90 mmHg or ongoing treatment.

RESULTS

The prevalence of borderline ISH (n = 203) by age was 4% in ages 40-49 years, 15% in ages 50-59 years, 28% in ages 60-69 years and 25% in ages 70-79 years. With borderline ISH as reference, normotensive subjects less often had fasting blood glucose > 5.5 mmol/l (odds ratio (OR): 0.4, 95% CI: 0.26-0.75), BMI > 27 kg/m2 (OR: 0.6, 95% confidence intervals (CI): 0.42-0.85) and known diabetes (OR: 0.4, 95% CI: 0.16-0.95). Hypertensive subjects more often had high density lipoprotein (HDL) cholesterol < 1.0 mmol/l (OR: 2.0, 95% CI: 1.35-2.99), a history of previous cardiovascular disease (CVD) (OR: 1.7, 95% CI: 1.01-2.72), known diabetes (OR: 2.4, 95% CI: 1.29-4.58) and microalbuminuria (men) (OR: 1.9, 95% CI: 1.15-3.11).

CONCLUSION

Borderline ISH is a common condition. It is associated with a more unfavourable risk factor profile than that of normotensive subjects concerning primarily glucose metabolism and obesity. The prevalence of known diabetes increased with the degree of hypertension.

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  • Authors+Show Affiliations

    ,

    Department of Community Medicine, Malmö University Hospital, Malmö, Sweden. fou-enheten.skara@swipnet.se

    , , ,

    Source

    Diabetes, obesity & metabolism 3:1 2001 Feb pg 25-31

    MeSH

    Adult
    Aged
    Aging
    Albuminuria
    Blood Glucose
    Cardiovascular Diseases
    Cholesterol, HDL
    Cross-Sectional Studies
    Diabetes Complications
    Fasting
    Female
    Humans
    Hypertension
    Male
    Middle Aged
    Obesity
    Odds Ratio
    Rural Population
    Sex Characteristics
    Sweden
    Systole

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11213596

    Citation

    Bøg-Hansen, E, et al. "Impaired Glucose Metabolism and Obesity in Swedish Patients With Borderline Isolated Systolic Hypertension: Skaraborg Hypertension and Diabetes Project." Diabetes, Obesity & Metabolism, vol. 3, no. 1, 2001, pp. 25-31.
    Bøg-Hansen E, Lindblad U, Ranstam J, et al. Impaired glucose metabolism and obesity in Swedish patients with borderline isolated systolic hypertension: Skaraborg Hypertension and Diabetes Project. Diabetes Obes Metab. 2001;3(1):25-31.
    Bøg-Hansen, E., Lindblad, U., Ranstam, J., Melander, A., & Råstam, L. (2001). Impaired glucose metabolism and obesity in Swedish patients with borderline isolated systolic hypertension: Skaraborg Hypertension and Diabetes Project. Diabetes, Obesity & Metabolism, 3(1), pp. 25-31.
    Bøg-Hansen E, et al. Impaired Glucose Metabolism and Obesity in Swedish Patients With Borderline Isolated Systolic Hypertension: Skaraborg Hypertension and Diabetes Project. Diabetes Obes Metab. 2001;3(1):25-31. PubMed PMID: 11213596.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impaired glucose metabolism and obesity in Swedish patients with borderline isolated systolic hypertension: Skaraborg Hypertension and Diabetes Project. AU - Bøg-Hansen,E, AU - Lindblad,U, AU - Ranstam,J, AU - Melander,A, AU - Råstam,L, PY - 2001/2/24/pubmed PY - 2001/3/17/medline PY - 2001/2/24/entrez SP - 25 EP - 31 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 3 IS - 1 N2 - AIM: To assess the prevalence of borderline isolated systolic hypertension (borderline ISH), and to examine its association with other cardiovascular risk factors. METHODS: A cross-sectional community-based study was carried out in 1993-1994 in Skara, Sweden, including 1109 randomly chosen subjects > or = 40 years old. Normotension (NT) was defined as systolic blood pressure (SBP) < 140 and diastolic blood pressure (DBP) < 90 mmHg, borderline ISH as SBP 140-159 and DBP < 90 mmHg and hypertension (HT) as SBP > or = 160 or DBP > or = 90 mmHg or ongoing treatment. RESULTS: The prevalence of borderline ISH (n = 203) by age was 4% in ages 40-49 years, 15% in ages 50-59 years, 28% in ages 60-69 years and 25% in ages 70-79 years. With borderline ISH as reference, normotensive subjects less often had fasting blood glucose > 5.5 mmol/l (odds ratio (OR): 0.4, 95% CI: 0.26-0.75), BMI > 27 kg/m2 (OR: 0.6, 95% confidence intervals (CI): 0.42-0.85) and known diabetes (OR: 0.4, 95% CI: 0.16-0.95). Hypertensive subjects more often had high density lipoprotein (HDL) cholesterol < 1.0 mmol/l (OR: 2.0, 95% CI: 1.35-2.99), a history of previous cardiovascular disease (CVD) (OR: 1.7, 95% CI: 1.01-2.72), known diabetes (OR: 2.4, 95% CI: 1.29-4.58) and microalbuminuria (men) (OR: 1.9, 95% CI: 1.15-3.11). CONCLUSION: Borderline ISH is a common condition. It is associated with a more unfavourable risk factor profile than that of normotensive subjects concerning primarily glucose metabolism and obesity. The prevalence of known diabetes increased with the degree of hypertension. SN - 1462-8902 UR - https://www.unboundmedicine.com/medline/citation/11213596/Impaired_glucose_metabolism_and_obesity_in_Swedish_patients_with_borderline_isolated_systolic_hypertension:_Skaraborg_Hypertension_and_Diabetes_Project_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1462-8902&amp;date=2001&amp;volume=3&amp;issue=1&amp;spage=25 DB - PRIME DP - Unbound Medicine ER -