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The relationship between wine consumption and cardiovascular risk: from epidemiological evidence to biological plausibility.
Ital Heart J 2001; 2(1):1-8IH

Abstract

Epidemiological studies have suggested that cardiovascular disease morbidity and mortality can be decreased by moderate alcohol consumption. Several recent studies have also separately assessed the relative risk associated with different types of alcoholic beverages. The evidence obtained strongly suggests, although does not prove, that there is a major beneficial effect from drinking a low-moderate amount of wine. A meta-analysis has recently been performed on 19 of these studies, selected on the basis of the availability of specific information on the relative risk associated with wine consumption. The results indicate a negative association of moderate (up to 300 ml per day) wine consumption with the risk of cardiovascular events. Although some cardioprotective effects of alcoholic beverages are probably due to ethanol-induced elevation of HDL cholesterol, lowering of fibrinogen plasma levels and, perhaps, of platelet aggregation, it is reasonable to speculate that the cardiovascular protective effects of wine, observed in French and in other populations, may be attributed in part to the antioxidant, vasorelaxant, and antithrombotic properties of its polyphenolic components.

Authors+Show Affiliations

Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, S. Maria Imbaro (CH), Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11214695

Citation

Rotondo, S, et al. "The Relationship Between Wine Consumption and Cardiovascular Risk: From Epidemiological Evidence to Biological Plausibility." Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, vol. 2, no. 1, 2001, pp. 1-8.
Rotondo S, Di Castelnuovo A, de Gaetano G. The relationship between wine consumption and cardiovascular risk: from epidemiological evidence to biological plausibility. Ital Heart J. 2001;2(1):1-8.
Rotondo, S., Di Castelnuovo, A., & de Gaetano, G. (2001). The relationship between wine consumption and cardiovascular risk: from epidemiological evidence to biological plausibility. Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, 2(1), pp. 1-8.
Rotondo S, Di Castelnuovo A, de Gaetano G. The Relationship Between Wine Consumption and Cardiovascular Risk: From Epidemiological Evidence to Biological Plausibility. Ital Heart J. 2001;2(1):1-8. PubMed PMID: 11214695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between wine consumption and cardiovascular risk: from epidemiological evidence to biological plausibility. AU - Rotondo,S, AU - Di Castelnuovo,A, AU - de Gaetano,G, PY - 2001/2/24/pubmed PY - 2001/6/8/medline PY - 2001/2/24/entrez SP - 1 EP - 8 JF - Italian heart journal : official journal of the Italian Federation of Cardiology JO - Ital Heart J VL - 2 IS - 1 N2 - Epidemiological studies have suggested that cardiovascular disease morbidity and mortality can be decreased by moderate alcohol consumption. Several recent studies have also separately assessed the relative risk associated with different types of alcoholic beverages. The evidence obtained strongly suggests, although does not prove, that there is a major beneficial effect from drinking a low-moderate amount of wine. A meta-analysis has recently been performed on 19 of these studies, selected on the basis of the availability of specific information on the relative risk associated with wine consumption. The results indicate a negative association of moderate (up to 300 ml per day) wine consumption with the risk of cardiovascular events. Although some cardioprotective effects of alcoholic beverages are probably due to ethanol-induced elevation of HDL cholesterol, lowering of fibrinogen plasma levels and, perhaps, of platelet aggregation, it is reasonable to speculate that the cardiovascular protective effects of wine, observed in French and in other populations, may be attributed in part to the antioxidant, vasorelaxant, and antithrombotic properties of its polyphenolic components. SN - 1129-471X UR - https://www.unboundmedicine.com/medline/citation/11214695/The_relationship_between_wine_consumption_and_cardiovascular_risk:_from_epidemiological_evidence_to_biological_plausibility_ L2 - https://medlineplus.gov/alcohol.html DB - PRIME DP - Unbound Medicine ER -