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A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism.
Clin Exp Obstet Gynecol. 2000; 27(3-4):203-6.CE

Abstract

OBJECTIVE

To compare the efficacy of finasteride and GnRH agonist in the treatment of idiopathic hirsutism.

METHODS

Sixty women with hirsutism were randomly assigned to receive either 5 mg of finasteride or long-acting GnRH agonist (depot leuprolide 3.75 mg) intramuscularly monthly for six months.

MAIN OUTCOME MEASURES

Hirsutism scores were measured according to the Ferriman-Gallway scoring system, and side-effects were monitored for six months of treatment. Blood samples were taken at each visit for assessment of endocrine (FSH, LH, estradiol, progesterone, total and free testosterone, androstenedione, DHEAS-S, 17-OH-P. SHBG), biochemical, and hematologic para- meters.

RESULTS

All of the patients treated with finasteride or GnRH agonist showed neither menstrual abnormalities nor side-effects. The mean percent change (+/- SD) in hirsutism scores in the GnRH and finasteride groups was 36% +/- 14% and 14% +/- 11% at six months, respectively. Serum total testosterone, free testosterone, androstenedion and DHEA-S showed a meaningful decrease in patients treated with GnRH agonist. On the other hand, only serum total testosterone and free testosterone levels decreased with finasteride treatment (p < 0.05 and p < 0.0001, respectively).

Authors+Show Affiliations

Bayhan G
Department of Obstetrics and Gynecology, Dicle University, Diyarbakir Turkey.
Bahçeci M
No affiliation info available
Demirkol T
No affiliation info available
Ertem M
No affiliation info available
Yalinkaya A
No affiliation info available
Erden AC
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdolescentAdultAndrostenedioneAnimalsDehydroepiandrosterone SulfateDelayed-Action PreparationsEnzyme InhibitorsEstrogens, Conjugated (USP)FemaleFinasterideFollicle Stimulating HormoneGonadotropin-Releasing HormoneHirsutismHorsesHumansLeuprolideLuteinizing HormoneMedroxyprogesterone AcetateTestosterone

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11214952

Citation

Bayhan, G, et al. "A Comparative Study of a Gonadotropin-releasing Hormone Agonist and Finasteride On Idiopathic Hirsutism." Clinical and Experimental Obstetrics & Gynecology, vol. 27, no. 3-4, 2000, pp. 203-6.
Bayhan G, Bahçeci M, Demirkol T, et al. A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism. Clin Exp Obstet Gynecol. 2000;27(3-4):203-6.
Bayhan, G., Bahçeci, M., Demirkol, T., Ertem, M., Yalinkaya, A., & Erden, A. C. (2000). A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism. Clinical and Experimental Obstetrics & Gynecology, 27(3-4), 203-6.
Bayhan G, et al. A Comparative Study of a Gonadotropin-releasing Hormone Agonist and Finasteride On Idiopathic Hirsutism. Clin Exp Obstet Gynecol. 2000;27(3-4):203-6. PubMed PMID: 11214952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism. AU - Bayhan,G, AU - Bahçeci,M, AU - Demirkol,T, AU - Ertem,M, AU - Yalinkaya,A, AU - Erden,A C, PY - 2001/2/24/pubmed PY - 2001/4/17/medline PY - 2001/2/24/entrez SP - 203 EP - 6 JF - Clinical and experimental obstetrics & gynecology JO - Clin Exp Obstet Gynecol VL - 27 IS - 3-4 N2 - OBJECTIVE: To compare the efficacy of finasteride and GnRH agonist in the treatment of idiopathic hirsutism. METHODS: Sixty women with hirsutism were randomly assigned to receive either 5 mg of finasteride or long-acting GnRH agonist (depot leuprolide 3.75 mg) intramuscularly monthly for six months. MAIN OUTCOME MEASURES: Hirsutism scores were measured according to the Ferriman-Gallway scoring system, and side-effects were monitored for six months of treatment. Blood samples were taken at each visit for assessment of endocrine (FSH, LH, estradiol, progesterone, total and free testosterone, androstenedione, DHEAS-S, 17-OH-P. SHBG), biochemical, and hematologic para- meters. RESULTS: All of the patients treated with finasteride or GnRH agonist showed neither menstrual abnormalities nor side-effects. The mean percent change (+/- SD) in hirsutism scores in the GnRH and finasteride groups was 36% +/- 14% and 14% +/- 11% at six months, respectively. Serum total testosterone, free testosterone, androstenedion and DHEA-S showed a meaningful decrease in patients treated with GnRH agonist. On the other hand, only serum total testosterone and free testosterone levels decreased with finasteride treatment (p < 0.05 and p < 0.0001, respectively). SN - 0390-6663 UR - https://www.unboundmedicine.com/medline/citation/11214952/A_comparative_study_of_a_gonadotropin_releasing_hormone_agonist_and_finasteride_on_idiopathic_hirsutism_ DB - PRIME DP - Unbound Medicine ER -